Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave ML7006, Cincinnati, OH, USA.
Curr Allergy Asthma Rep. 2012 Oct;12(5):448-55. doi: 10.1007/s11882-012-0276-1.
Allergic asthma is on the rise in developed countries, and cockroach exposure is a major risk factor for the development of asthma. In recent years, a number of studies have investigated the importance of allergen-associated proteases in modulating allergic airway inflammation. Many of the studies have suggested the importance of allergen-associated proteases as having a direct role on airway epithelial cells and dendritic cells. In most cases, activation of the protease activated receptor (PAR)-2 has been implicated as a mechanism behind the potent allergenicity associated with cockroaches. In this review, we focus on recent evidence linking cockroach proteases to activation of a variety of cells important in allergic airway inflammation and the role of PAR-2 in this process. We will highlight recent data exploring the potential mechanisms involved in the biological effects of the allergen.
在发达国家，过敏性哮喘的发病率呈上升趋势，而蟑螂暴露是哮喘发展的一个主要危险因素。近年来，许多研究调查了过敏原相关蛋白酶在调节过敏性气道炎症中的重要性。许多研究表明，过敏原相关蛋白酶在气道上皮细胞和树突状细胞中具有直接作用，这一点非常重要。在大多数情况下，蛋白酶激活受体（PAR）-2 的激活被认为是与蟑螂相关的强烈变应原性的机制之一。在这篇综述中，我们重点关注最近的证据，这些证据将蟑螂蛋白酶与激活各种在过敏性气道炎症中重要的细胞联系起来，并探讨了 PAR-2 在这一过程中的作用。我们将强调最近的数据，这些数据探讨了过敏原的生物学效应所涉及的潜在机制。
