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肠易激综合征何时并非肠易激综合征?慢性功能性腹痛的诊断与治疗。

When is irritable bowel syndrome not irritable bowel syndrome? Diagnosis and treatment of chronic functional abdominal pain.

作者信息

Grover Madhusudan

机构信息

Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN 55905, USA.

出版信息

Curr Gastroenterol Rep. 2012 Aug;14(4):290-6. doi: 10.1007/s11894-012-0270-8.

Abstract

Functional abdominal pain syndrome (FAPS) is a distinct chronic gastrointestinal (GI) pain disorder characterized by the presence of constant or frequently recurring abdominal pain that is not associated with eating, change in bowel habits, or menstrual periods. The pain experience in FAPS is predominantly centrally driven as compared to other chronic painful GI conditions such as inflammatory bowel disease and chronic pancreatitis where peripherally acting factors play a major role in driving the pain. Psychosocial factors are often integrally associated with the disorder and can pose significant challenges to evaluation and treatment. Patients suffer from considerable loss of function, which can drive health care utilization. Treatment options are limited at best with most therapeutic regimens extrapolated from pain management of other functional GI disorders and chronic pain conditions. A comprehensive approach to management using a biopsychosocial construct and collaboration with pain specialists and psychiatry is most beneficial to the management of this disorder.

摘要

功能性腹痛综合征(FAPS)是一种独特的慢性胃肠道疼痛疾病,其特征是存在持续或频繁复发的腹痛,且与进食、排便习惯改变或月经周期无关。与其他慢性疼痛性胃肠道疾病(如炎症性肠病和慢性胰腺炎,其中外周作用因素在疼痛发生中起主要作用)相比,FAPS的疼痛体验主要由中枢驱动。社会心理因素通常与该疾病密切相关,可能给评估和治疗带来重大挑战。患者会出现相当程度的功能丧失,这可能导致医疗保健的使用。治疗选择充其量有限,大多数治疗方案是从其他功能性胃肠道疾病和慢性疼痛状况的疼痛管理中推断出来的。采用生物心理社会模式的综合管理方法,并与疼痛专家和精神病学合作,对该疾病的管理最为有益。

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