BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Curr Osteoporos Rep. 2012 Sep;10(3):208-16. doi: 10.1007/s11914-012-0106-3.
The relationship between body composition and skeletal metabolism has received growing recognition. Low body weight is an established risk factor for fracture. The effect of obesity on skeletal health is less well defined. Extensive studies in patients with anorexia nervosa and obesity have illuminated many of the underlying biologic mechanisms by which body composition modulates bone mass. This review examines the relationship between body composition and bone mass through data from recent research studies throughout the weight spectrum ranging from anorexia nervosa to obesity.
人体成分与骨骼代谢之间的关系受到越来越多的关注。体重过低是骨折的既定风险因素。肥胖对骨骼健康的影响则不太明确。在神经性厌食症和肥胖症患者中的广泛研究阐明了许多通过调节骨量的人体成分的潜在生物学机制。本综述通过从神经性厌食症到肥胖症的整个体重范围内的最新研究数据来研究人体成分与骨量之间的关系。