Department of Psychology, University of Delaware, Newark, DE 19716, USA.
Dev Psychobiol. 2013 Jul;55(5):483-95. doi: 10.1002/dev.21052. Epub 2012 May 29.
In rodents, voluntary exercise and environmental complexity increases hippocampal neurogenesis and reverses spatial learning and long-term potentiation deficits in animals prenatally exposed to alcohol. The present experiment extended these findings to neonatal alcohol exposure and to delay, trace, and contextual fear conditioning. Rats were administered either 5.25 g/kg/day alcohol via gastric intubation or received sham-intubations (SI) between Postnatal Day (PD) 4 and 9 followed by either free access to a running wheel on PD 30-41 and housing in a complex environment on PD 42-72 (wheel-running plus environmental complexity; WREC) or conventional social housing (SHSH) from PD 30 to 72. Adult rats (PD 80 ± 5) received 5 trials/day of a 10-s flashing-light conditioned stimulus (CS) paired with .8 mA footshock either immediately (delay conditioning) or after a 10-s trace interval (trace conditioning) for 2 days. Neonatal alcohol exposure impaired context and trace conditioning, but not short-delay conditioning. The WREC intervention did not reverse these deficits, despite increasing context-related freezing in ethanol-exposed and SI animals.
在啮齿动物中，自愿运动和环境复杂性增加了海马神经发生，并逆转了产前暴露于酒精的动物的空间学习和长时程增强缺陷。本实验将这些发现扩展到了新生期酒精暴露以及延迟、痕迹和情境恐惧条件反射。大鼠在出生后第 4 天至第 9 天期间通过胃管给予 5.25 g/kg/天酒精或接受假灌胃（SI），然后在第 30 天至第 41 天期间自由使用跑步轮，并在第 42 天至第 72 天期间在复杂环境中饲养（轮跑加环境复杂性；WREC）或从第 30 天到第 72 天在传统的社会住房（SHSH）中饲养。成年大鼠（PD80±5）在 2 天内每天接受 5 次 10 秒闪烁光条件刺激（CS）与.8 mA 足底电击配对，要么立即（延迟条件反射），要么在 10 秒的痕迹间隔后（痕迹条件反射）。新生期酒精暴露损害了情境和痕迹条件反射，但不损害短延迟条件反射。尽管增加了乙醇暴露和 SI 动物与情境相关的冻结，但 WREC 干预并没有逆转这些缺陷。
