Chen Fangguo, Chen Guiling, Dou Yan, Xu Xinyun
Department of Oncology, 88 Hospital of PLA, Tai'an, People's Republic of China.
Department of Internal Medicine, Suncun Hospital of Shandong Xinwen Mining Group, Xintai, People's Republic of China.
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):851-7. doi: 10.1177/1470320315588234. Epub 2015 Jun 3.
Previous studies on the relationship between angiotensin ІІ type 1 receptor (AT1R) gene (A1166C) polymorphism and breast cancer did not reach the same conclusion. In the present study, we aimed to further evaluate the relationship between the AT1R gene A1166C polymorphism and breast cancer risk.
We selected five case-control studies related to AT1R gene A1166C polymorphism and breast cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, Chinese CNKI, Web of Science, and the Wanfang database. We utilized Q-test and I(2) test to detect the heterogeneity between each study. A random-effects model (I(2) > 50%; p < 0.10) or a fixed-effects model (I(2) < 50%; p > 0.10) was utilized to merge the odds ratio (OR) and 95% confidence interval (CI) during the meta- analyses.
The present study included 972 patients with breast cancer and 1336 cancer-free control subjects. By meta-analysis, we found A1166C polymorphism was associated with decreased risk for breast cancer in Caucasian population in an additive model (C vs. T: OR = 0.77, 95% CI: 0.62-0.96, p = 0.02). However, we did not find associations in other genetic models (AC+CC vs. AA: OR = 0.78, 95% CI: 0.50-1.22, p = 0.28; CC vs. AA+AC: OR = 1.64, 95% CI: 0.94-2.85, p = 0.08).
We concluded that AT1R gene A1166C polymorphism was associated with reduced risk for breast cancer.
既往关于血管紧张素Ⅱ1型受体（AT1R）基因（A1166C）多态性与乳腺癌关系的研究未得出一致结论。在本研究中，我们旨在进一步评估AT1R基因A1166C多态性与乳腺癌风险之间的关系。
通过检索PubMed、EMBase、中国生物医学文献数据库、中国知网、Web of Science和万方数据库，我们选取了五项与AT1R基因A1166C多态性和乳腺癌相关的病例对照研究。我们使用Q检验和I²检验来检测各研究之间的异质性。在荟萃分析中，采用随机效应模型（I²>50%；p<0.10）或固定效应模型（I²<50%；p>0.10）合并比值比（OR）和95%置信区间（CI）。
本研究纳入了972例乳腺癌患者和1336例无癌对照受试者。通过荟萃分析，我们发现A1166C多态性在加性模型中与白种人群乳腺癌风险降低相关（C与T相比：OR = 0.77，95%CI：0.62 - 0.96，p = 0.02）。然而，我们在其他遗传模型中未发现相关性（AC + CC与AA相比：OR = 0.78，95%CI：0.50 - 1.22，p = 0.28；CC与AA + AC相比：OR = 1.64，95%CI：0.94 - 2.85，p = 0.08）。
我们得出结论，AT1R基因A1166C多态性与乳腺癌风险降低相关。
