Department of Respiratory Diseases, Clinic University Hospital, Santiago de Compostela, Spain.
Eur J Public Health. 2013 Aug;23(4):706-10. doi: 10.1093/eurpub/cks061. Epub 2012 May 29.
Paracetamol is one of the factors that have been associated with the observed increase in asthma prevalence in the last few years. The influence of environmental or genetic factors in this disease may be different in some countries than in others. The purpose of this study was to analyse the relationship between the paracetamol consumption and asthma prevalence in our community.
A cross-sectional study was conducted on more than 20,000 children and adolescents in Galicia, Spain. The International Study of Asthma and Allergies in Childhood methodology was used to collect the information on asthma symptoms in children, paracetamol consumption, body mass index (BMI), pets in the home, education level of the mother and parental asthma and smoking habits. The influence of paracetamol consumption on the prevalence of asthma symptoms was calculated using logistic regression, adjusted for the other parameters included in the study.
After adjusting for gender, BMI, having a cat or dog, maternal education, parental asthma and smoking, in 6- to 7-year-old children, the consumption of paracetamol during the first year of life is associated with asthma [odds ratio (OR) 2.04 (1.79-2.31) for wheezing at some time]. Paracetamol consumption in the previous year leads to a significant increase in the probability of wheezing at some time [OR 3.32 (2.51-4.41)] in young children and adolescents [OR 2.12 (1.68-2.67)].
Paracetamol consumption is associated with a significant increase in asthma symptoms. The effect is greater the more often the drug is taken.
在过去几年中，对乙酰氨基酚是与哮喘发病率上升相关的因素之一。这种疾病的环境或遗传因素的影响在不同国家可能有所不同。本研究旨在分析我们社区中对乙酰氨基酚消费与哮喘发病率之间的关系。
对西班牙加利西亚的 20,000 多名儿童和青少年进行了横断面研究。采用儿童哮喘和过敏国际研究方法收集儿童哮喘症状、对乙酰氨基酚消费、体重指数（BMI）、家中宠物、母亲教育程度、父母哮喘和吸烟习惯等信息。使用逻辑回归分析对乙酰氨基酚消费对哮喘症状发病率的影响，同时调整研究中包含的其他参数。
调整性别、BMI、家中有猫或狗、母亲教育程度、父母哮喘和吸烟习惯后，在 6-7 岁儿童中，生命第一年的对乙酰氨基酚消费与哮喘有关[喘息的比值比（OR）为 2.04（1.79-2.31）]。前一年的对乙酰氨基酚消费显著增加了儿童和青少年在任何时候喘息的概率[OR 3.32（2.51-4.41）]和[OR 2.12（1.68-2.67）]。
对乙酰氨基酚消费与哮喘症状显著增加相关。服用药物的频率越高，效果越明显。
