Sakulchit Teeranai, Goldman Ran D
Can Fam Physician. 2017 Mar;63(3):211-213.
A child with a history of asthma came to my clinic with acute fever. I have heard that acetaminophen might be associated with exacerbation of asthma. Is it safe if I recommend acetaminophen for this child? Most studies suggest an association between acetaminophen use in children and development of asthma later in childhood. However, several confounding factors in study design might contribute to this positive correlation, and without a prospective controlled trial, confirming this finding is challenging. If children have a known history of asthma, it is likely safe to administer a single dose of acetaminophen without concern of precipitating adverse respiratory symptoms. Regular use of acetaminophen to relieve fever or pain does not seem to exacerbate asthma in children more than ibuprofen does.
一名有哮喘病史的儿童因急性发热前来我的诊所。我听说对乙酰氨基酚可能与哮喘加重有关。我给这个孩子推荐对乙酰氨基酚安全吗？大多数研究表明儿童使用对乙酰氨基酚与儿童后期哮喘的发生有关。然而，研究设计中的几个混杂因素可能导致这种正相关，而且没有前瞻性对照试验，证实这一发现具有挑战性。如果儿童有已知的哮喘病史，给予单剂量对乙酰氨基酚可能是安全的，不用担心引发不良呼吸道症状。与布洛芬相比，常规使用对乙酰氨基酚来缓解发热或疼痛似乎并不会使儿童哮喘加重得更多。
