Chow J M, Gotsis E D, Jarc M, Dillon J T, Wyrwicz A M, Applebaum E L
Department of Otolaryngology-Head and Neck Surgery, University of Illinois College of Medicine, Chicago.
Am J Otolaryngol. 1990 Sep-Oct;11(5):332-8. doi: 10.1016/0196-0709(90)90064-3.
Proton nuclear magnetic resonance spectroscopy was used to evaluate changes in plasma lipoproteins in patients with squamous cell head and neck cancer. Plasma from 14 patients was analyzed by proton nuclear magnetic resonance spectroscopy, and line widths and fast and slow methyl and methylene transverse relaxation values were obtained. In addition, the lipid and lipoprotein concentrations in the sera of these patients were measured by standard biochemical techniques. Preliminary results suggested that squamous cell carcinomas of the head and neck with nodal metastases are associated with measureable changes in slow methylene transverse relaxation values, as compared with controls. These findings indicate the presence of a new lipoprotein complex in patients with squamous cell carcinomas of the head and neck with nodal metastases.
质子核磁共振光谱法用于评估头颈部鳞状细胞癌患者血浆脂蛋白的变化。对14例患者的血浆进行质子核磁共振光谱分析，获得线宽以及甲基和亚甲基的快速和慢速横向弛豫值。此外，通过标准生化技术测量这些患者血清中的脂质和脂蛋白浓度。初步结果表明，与对照组相比，伴有淋巴结转移的头颈部鳞状细胞癌与慢速亚甲基横向弛豫值的可测量变化有关。这些发现表明，伴有淋巴结转移的头颈部鳞状细胞癌患者体内存在一种新的脂蛋白复合物。
