Laboratory of Reproductive Biology, The Juliane Marie Center for Women, Children & Reproduction, University Hospital of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Future Oncol. 2012 May;8(5):595-608. doi: 10.2217/fon.12.47.
Girls and women suffering from a cancer that requires treatment with gonadotoxic drugs may experience cessation of reproductive function as a side effect due to obliteration of the ovarian pool of follicles. Techniques are now available for fertility preservation, such as cryopreservation of mature oocytes, embryos or ovarian cortical tissue. Whereas collection of mature oocytes and embryos requires at least a 2-week period, ovarian tissue may on short notice be frozen prior to treatment and can be transplanted back into women with ovarian failure. Transplanted frozen/thawed tissue supports survival and growth of follicles, giving rise to menstrual cycles and hormone production for several years. Worldwide, the procedure has resulted in the birth of 15 healthy children. Many cancer patients including girls and young women want fertility preservation, and the techniques are now being further developed and implemented in several centers.
患有需要性腺毒性药物治疗的癌症的女孩和妇女可能会因卵泡池破坏而出现生殖功能停止这一副作用。目前有一些生育力保存技术，如成熟卵母细胞、胚胎或卵巢皮质组织的冷冻保存。虽然采集成熟卵母细胞和胚胎至少需要 2 周的时间，但在治疗前可以随时将卵巢组织冷冻，并可在卵巢功能衰竭的妇女中进行移植。移植的冷冻/解冻组织支持卵泡的存活和生长，使妇女在数年内出现月经周期和激素产生。在全球范围内，该程序已导致 15 名健康儿童的诞生。许多癌症患者，包括女孩和年轻妇女，都希望保留生育能力，目前这些技术正在几个中心进一步开发和实施。
