Oral Care Center for Inherited Diseases, University Hospital of Brasilia, Department of Dentistry, School of Health Science, University of Brasilia, Brazil.
Arch Oral Biol. 2012 Aug;57(8):1062-9. doi: 10.1016/j.archoralbio.2012.04.006. Epub 2012 May 28.
An association between tooth agenesis and taurodontism has been suggested. To verify if tooth agenesis and taurodontism are associated within families and specific patterns of tooth agenesis, this study aims to compare the frequency of taurodontism in patients with nonsyndromic familial tooth agenesis, their first and second-degree relatives with complete permanent dentition and a control group of unrelated healthy individuals with complete permanent dentition.
Panoramic radiographs of patients with nonsyndromic familial tooth agenesis, their first and second-degree relatives and a control group of individuals with complete permanent dentition were examined. Taurodontism was assessed on permanent mandibular first molars. The difference in the frequency of taurodontism among the studied groups was tested with Fisher's Exact Test.
Seventeen families with nonsyndromic familial tooth agenesis were studied. The frequency of taurodontism was 29% in patients with tooth agenesis, 10.3% in their first and second degree relatives, and 6.6% in the control group. A significant statistical difference among the studied groups was observed (p=0.002). Taurodontism was proportionally more frequent in patients with a higher number of absent teeth. It was mainly observed in patients from families in which the proband was diagnosed with oligodontia.
Taurodontism is more frequent in nonsyndromic familial tooth agenesis. Individuals in families with second premolar and molar oligodontia are more likely to have taurodontism, even the individuals with complete dentition. This association could define a subphenotype for future genetic studies of dental development.
有研究表明，牙缺失与尖牙畸形之间存在关联。为了验证牙缺失与尖牙畸形是否存在家族内关联，以及特定类型的牙缺失与尖牙畸形之间是否存在关联，本研究旨在比较非综合征型家族性牙缺失患者、其一级和二级亲属（具有完整恒牙列）与无牙颌相关的健康个体（具有完整恒牙列）之间尖牙畸形的频率。
检查了非综合征型家族性牙缺失患者、其一级和二级亲属以及具有完整恒牙列的无牙颌相关健康个体的全景片。在恒下第一磨牙上评估尖牙畸形。使用 Fisher 确切检验检验研究组之间尖牙畸形频率的差异。
研究了 17 个非综合征型家族性牙缺失的家庭。牙缺失患者的尖牙畸形频率为 29%，其一级和二级亲属为 10.3%，对照组为 6.6%。研究组之间存在显著的统计学差异（p=0.002）。缺失牙数量较多的患者中，尖牙畸形的比例更高。主要发生在诊断为少牙症的患者的家庭中。
非综合征型家族性牙缺失中尖牙畸形更为常见。第二前磨牙和磨牙少牙症的家族成员更有可能出现尖牙畸形，即使他们具有完整的恒牙列。这种关联可以为未来的牙发育遗传研究定义一个亚表型。
