Oborin V A, Vasil'ev N T, Vasil'ev P G
Antibiot Khimioter. 1990 Aug;35(8):37-9.
Rapid estimation of the protective effect of antibacterial drugs on Fransiella tularensis for not more than 2 days was shown possible in experiments on albino mice infected with tularemia. High efficacy of aminoglycosides (kanamycin, gentamicin, streptomycin, amikacin, netilmicin, tobramycin, sagamycin, ribostamycin and sisomicin), tetracyclines (tetracycline, doxycycline, minocycline and methacycline), rifampicin, phosphomycin and oxolinic acid was determined with the recommended rapid method. Amoxycillin, ampicillin, piperacillin, carbenicillin, erythromycin, levomycetin, cefradine, cefmetazole, cefatrizine, cefoxitin, cefsulodin and bactrim (biseptol) proved to be inefficient against the tularemia causative agent.
在对白化病小鼠进行的土拉菌病感染实验中，已表明有可能在不超过2天的时间内快速评估抗菌药物对土拉热弗朗西斯菌的保护作用。使用推荐的快速方法测定了氨基糖苷类（卡那霉素、庆大霉素、链霉素、阿米卡星、奈替米星、妥布霉素、沙加霉素、核糖霉素和西索米星）、四环素类（四环素、强力霉素、米诺环素和甲烯土霉素）、利福平、磷霉素和恶喹酸的高效性。阿莫西林、氨苄西林、哌拉西林、羧苄西林、红霉素、氯霉素、头孢拉定、头孢美唑、头孢替嗪、头孢西丁、头孢磺啶和复方新诺明（双嘧啶片）被证明对土拉菌病病原体无效。
