D'iakov S I, Bubnov V P, Lebedeva I K, Sidorenko S V, Moskalenko V I
Research Institute of Military Medicine, Ministry of Defence of the Russian Federation, St. Petersburg.
Antibiot Khimioter. 1998;43(3):22-6.
The protective effects of doxycycline, rifampicin and sisomicin were compared in a multifactor experiment with animal infection induced by finally dispersed aerosol of a virulent strain of the European variant of the tularemia causative agent and the optimal regimens for the antibiotic use were determined. By the values of the protective effect rifampicin and sisomicin were shown to provide a high percentage of the animal survival: more than 80 and up to 50-70 per cent of the animals survived when the aerosol infective doses were 100 and 10,000 LD50, respectively. A characteristic feature of doxycycline was its activity only in the infection induced by low doses of the biological agent. The optimal course of the antibiotic therapy in inhalation tularemia was 6 to 8 days. The interval of 1 to 3 days between the infection and the therapy start had no significant effect on the protective efficacies of the antibiotics.
在一项多因素实验中，比较了强力霉素、利福平及西索米星对由土拉热病原菌欧洲变种强毒株的最终分散气溶胶诱发的动物感染的保护作用，并确定了抗生素使用的最佳方案。从保护作用的值来看，利福平和西索米星显示能使高比例的动物存活：当气溶胶感染剂量分别为100和10000 LD50时，分别有超过80%和高达50%-70%的动物存活。强力霉素的一个特征是仅在低剂量生物制剂诱发的感染中有活性。吸入性土拉热抗生素治疗的最佳疗程为6至8天。感染与治疗开始之间1至3天的间隔对这些抗生素的保护效果无显著影响。
