Takanashi Minoko, Odajima Takeshi, Aota Seiko, Sudoh Mitsuaki, Yamaga Yoshio, Ono Yuriko, Yoshinaga Kentaro, Motoji Toshiko, Matsuzaki Koji, Satake Masahiro, Sugimori Hiroki, Nakajima Kazunori
Japanese Red Cross Tokyo Blood Centre, Tokyo 135-8639, Japan.
Transfus Apher Sci. 2012 Dec;47(3):319-25. doi: 10.1016/j.transci.2012.04.002. Epub 2012 May 28.
Vasovagal reaction (VVR) is the most frequent side effect at blood collection sites.
To protect donors, factors contributing to VVR were analysed.
Complications following whole blood and apheresis donations have been recorded and accumulated by the Japanese Red Cross Tokyo Blood Centre. A dataset of 43,948 donors who had no complications was prepared as a control by randomly selecting days in each season in the 2006 and 2007 fiscal years. Factors contributing to 4924 VVR incidents in the 2006 and 2007 fiscal years were analysed by univariate and multivariate logistic regression.
The age, weight, body mass index (BMI), predonation systolic and diastolic pressure, and circulating blood volume were lower, and the pulse was higher, for the VVR group compared to the control group (p<0.0001). The VVR group had more female donors, less sleep, and more time since a meal than the control. In multivariate analysis, significant risk factors for 400 ml whole blood donors, which are the majority of donors, were an age <50 years, being female, a BMI <25, pulse ≥90/min, sleep duration <8 h, the time after eating ≥4 h, a first time donation and circulating blood volume of <4.3 l. Sleep duration of <6 h was shown to be a VVR risk as much as a first time donation.
From our analysis, the amount of sleep obtained the previous night should be considered at the reception of donors.
血管迷走神经反应（VVR）是采血点最常见的副作用。
为保护献血者，分析导致VVR的因素。
日本红十字会东京血液中心记录并积累了全血和单采献血后的并发症情况。通过随机选择2006财年和2007财年每个季节的日期，准备了一个由43948名无并发症献血者组成的数据集作为对照。通过单因素和多因素逻辑回归分析2006财年和2007财年4924例VVR事件的影响因素。
与对照组相比，VVR组的年龄、体重、体重指数（BMI）、献血前收缩压和舒张压以及循环血量较低，脉搏较高（p<0.0001）。VVR组女性献血者更多，睡眠更少，进食后时间更长。在多因素分析中，对于大多数献血者（400ml全血献血者）来说，显著的危险因素包括年龄<50岁、女性、BMI<25、脉搏≥90次/分钟、睡眠时间<8小时、进食后时间≥4小时、首次献血以及循环血量<4.3升。睡眠时间<6小时被证明与首次献血一样是VVR的危险因素。
根据我们的分析，在接待献血者时应考虑前一晚的睡眠量。
