Rohra D K, Juriasinghani V, Rai K, Azam S I
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
Transfus Med. 2010 Jun;20(3):129-33. doi: 10.1111/j.1365-3148.2009.00984.x. Epub 2009 Dec 2.
Vasovagal reaction (VVR) is a very common adverse event related to blood donation. No study has been conducted in Pakistan to estimate the prevalence of VVR in blood donors. This study was conducted to estimate the prevalence of immediate VVR in blood donors of Karachi, Pakistan. The study was conducted in two blood banks of Karachi. Data regarding the development of immediate VVR were documented. The effect of blood donation on vital parameters like pulse rate, blood pressure (BP), temperature and respiratory rate was also observed. Six hundred and seventy-four blood donors were recruited. All the donors who consented were males. Weakness and dizziness were two most common symptoms which were reported by 91 (13.5%) and 73 (10.8%) of the participants, respectively. Out of 91 donors in whom signs and symptoms of immediate VVR were observed, a significant drop in systolic BP (13.5 +/- 2.5 mmHg) and decrease in pulse rate (13.3 +/- 3.6) were concurrently noted in 55 donors (8.2% of all the participants). There was lack of association of age, body mass index (BMI), estimated blood volume, ethnicity, educational status, profession and first time donation status with the frequency of VVR. Only marital status was found to be significantly associated with higher frequency of immediate VVR, where married donors were having higher odds as compared to singles. The prevalence of VVR in the blood donors at two blood banks of Karachi is at least 8.2%. Furthermore, married men are at more risk of experiencing VVR in our population.
血管迷走神经反应（VVR）是一种与献血相关的非常常见的不良事件。巴基斯坦尚未开展研究来估计献血者中VVR的患病率。本研究旨在估计巴基斯坦卡拉奇献血者中即时VVR的患病率。该研究在卡拉奇的两家血库进行。记录了有关即时VVR发生情况的数据。还观察了献血对脉搏率、血压（BP）、体温和呼吸率等生命体征参数的影响。招募了674名献血者。所有同意参与的献血者均为男性。虚弱和头晕是最常见的两种症状，分别有91名（13.5%）和73名（10.8%）参与者报告出现这些症状。在91名观察到即时VVR体征和症状的献血者中，55名献血者（占所有参与者的8.2%）同时出现收缩压显著下降（13.5±2.5 mmHg）和脉搏率降低（13.3±3.6）。VVR的发生频率与年龄、体重指数（BMI）、估计血容量、种族、教育程度、职业和首次献血状态之间缺乏关联。仅发现婚姻状况与即时VVR的较高发生频率显著相关，已婚献血者出现VVR的几率高于单身献血者。卡拉奇两家血库的献血者中VVR的患病率至少为8.2%。此外，在我们的人群中，已婚男性发生VVR的风险更高。
