Hospital Universitario Insular de las Palmas de Gran Canaria, Universidad de Las Palmas de Gran Canaria, Spain.
Int J Oral Maxillofac Surg. 2012 Nov;41(11):1410-5. doi: 10.1016/j.ijom.2012.04.020. Epub 2012 May 28.
Platelet-rich plasma is a concentrate of growth factors and osteoconductive proteins, which can play a major role in bone biology by accelerating and enhancing bone repair and regeneration. This paper describes the results of using platelet-rich plasma in the management of bisphosphonate-associated necrosis of the jaw. Eight patients with a diagnosis of bisphosphonate-associated necrosis of the jaw were surgically treated for debridement and removal of necrotic bone, followed by application of autologous platelet concentrate enriched with growth factors and primary suture of the wound. Patients underwent periodic clinical and radiological follow-up examinations. All patients showed clinical improvement and oral lesions resolved 2-4 weeks after treatment. After an average 14-month follow up period, patients remained asymptomatic. Although not conclusive, the combination of necrotic-bone curettage and platelet-rich-plasma to treat refractory osteonecrosis of the jaw yielded promising results.
富血小板血浆是一种生长因子和骨诱导蛋白的浓缩物，它可以通过加速和增强骨修复和再生在骨生物学中发挥重要作用。本文描述了使用富血小板血浆治疗双膦酸盐相关性颌骨坏死的结果。8 名经诊断患有双膦酸盐相关性颌骨坏死的患者接受了清创和坏死骨切除手术，随后应用富含生长因子的自体血小板浓缩物，并对伤口进行了一期缝合。患者接受了定期的临床和影像学随访检查。所有患者均表现出临床改善，治疗后 2-4 周口腔病变消退。平均 14 个月的随访期后，患者仍无症状。虽然没有定论，但坏死骨刮除术联合富血小板血浆治疗难治性颌骨骨坏死的效果令人满意。
