Department of Obstetrics and Gynaecology, National Taiwan University Hospital and National Taiwan University College of Medicine, 8, Chung-Shan South Road, Taipei, Taiwan.
Best Pract Res Clin Obstet Gynaecol. 2012 Dec;26(6):817-27. doi: 10.1016/j.bpobgyn.2012.04.004. Epub 2012 May 29.
Ovarian hyperstimulation syndrome is a relatively common complication of ovarian stimulation and can be life-threatening. The pathophysiology of ovarian hyperstimulation syndrome is characterised by increased capillary permeability, leading to leakage of fluid from the vascular compartment, with third space fluid accumulation and intravascular dehydration. The combined use of a gonadotrophin-releasing hormone antagonist protocol with gonadotrophin-releasing hormone agonist triggering and oocyte and embryo freezing has considerable promise in preventing ovarian hyperstimulation syndrome. Women with severe ovarian hyperstimulation syndrome require hospitalisation for more careful monitoring and treatment. Transvaginal paracentesis can be used as an outpatient treatment to prevent the need for hospitalisation. The inhibition of vascular permeability seems to be a novel therapeutic approach to preventing and treating ovarian hyperstimulation syndrome.
卵巢过度刺激综合征是卵巢刺激的一种相对常见的并发症，可能危及生命。卵巢过度刺激综合征的病理生理学特征为毛细血管通透性增加，导致血管腔内液体渗漏，第三间隙液体蓄积和血管内脱水。促性腺激素释放激素拮抗剂方案联合使用促性腺激素释放激素激动剂触发和卵母细胞及胚胎冷冻具有很大的预防卵巢过度刺激综合征的潜力。严重卵巢过度刺激综合征的女性需要住院以便更仔细地监测和治疗。经阴道穿刺术可作为门诊治疗，以避免住院。抑制血管通透性似乎是预防和治疗卵巢过度刺激综合征的一种新的治疗方法。
