造血干细胞黏附与迁移的分子机制。
Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells.
机构信息
Department of Hematology and Erasmus MC Stem Cell Institute for Regenerative Medicine, Erasmus MC, Rotterdam, The Netherlands.
出版信息
Cell Adh Migr. 2012 Jan-Feb;6(1):39-48. doi: 10.4161/cam.18975.
Abstract
Hematopoietic stem cell transplantation is the most powerful treatment modality for a large number of hematopoietic malignancies, including leukemia. Successful hematopoietic recovery after transplantation depends on homing of hematopoietic stem cells to the bone marrow and subsequent lodging of those cells in specific niches in the bone marrow. Migration of hematopoietic stem cells to the bone marrow is a highly regulated process that requires correct regulation of the expression and activity of various molecules including chemoattractants, selectins and integrins. This review will discuss recent studies that have extended our understanding of the molecular mechanisms underlying adhesion, migration and bone marrow homing of hematopoietic stem cells.
摘要
造血干细胞移植是治疗大量血液恶性肿瘤（包括白血病）的最有效治疗方法。移植后成功的造血恢复取决于造血干细胞归巢到骨髓，以及随后这些细胞在骨髓中的特定龛位定居。造血干细胞向骨髓的迁移是一个高度调控的过程，需要正确调节各种分子的表达和活性，包括趋化因子、选择素和整合素。本文综述将讨论最近的研究，这些研究扩展了我们对造血干细胞黏附、迁移和归巢骨髓的分子机制的理解。
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