造血干细胞黏附与迁移的分子机制。
Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells.
机构信息
Department of Hematology and Erasmus MC Stem Cell Institute for Regenerative Medicine, Erasmus MC, Rotterdam, The Netherlands.
出版信息
Cell Adh Migr. 2012 Jan-Feb;6(1):39-48. doi: 10.4161/cam.18975.
Abstract
Hematopoietic stem cell transplantation is the most powerful treatment modality for a large number of hematopoietic malignancies, including leukemia. Successful hematopoietic recovery after transplantation depends on homing of hematopoietic stem cells to the bone marrow and subsequent lodging of those cells in specific niches in the bone marrow. Migration of hematopoietic stem cells to the bone marrow is a highly regulated process that requires correct regulation of the expression and activity of various molecules including chemoattractants, selectins and integrins. This review will discuss recent studies that have extended our understanding of the molecular mechanisms underlying adhesion, migration and bone marrow homing of hematopoietic stem cells.
摘要
造血干细胞移植是治疗大量血液恶性肿瘤（包括白血病）的最有效治疗方法。移植后成功的造血恢复取决于造血干细胞归巢到骨髓，以及随后这些细胞在骨髓中的特定龛位定居。造血干细胞向骨髓的迁移是一个高度调控的过程，需要正确调节各种分子的表达和活性，包括趋化因子、选择素和整合素。本文综述将讨论最近的研究，这些研究扩展了我们对造血干细胞黏附、迁移和归巢骨髓的分子机制的理解。
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本文引用的文献
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Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors.造血移植的预处理会激活补体级联反应，并在骨髓中诱导产生蛋白水解环境：生物活性脂质和可溶性 C5b-C9 作为归巢因子的新作用。
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Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells.分析人源和鼠源富含造血干/祖细胞的骨髓细胞表面 E-选择糖蛋白配体。
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Stromal cell-derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation.基质细胞衍生因子-1 与造血细胞归巢在成年斑马鱼造血细胞移植模型中的作用。
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