鼠骨髓瘤MOPC - 315产生的C型病毒和免疫球蛋白A：两种独立的活性

Type C virus and immunoglobulin A production by murine myeloma MOPC-315: two independent activities.

作者信息

Gazit A, Yaniv A, Halperin D, Ben-Efraim S

出版信息

Infect Immun. 1979 Aug;25(2):569-73. doi: 10.1128/iai.25.2.569-573.1979.

DOI:10.1128/iai.25.2.569-573.1979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414482/

Abstract

The suspected correlation between cessation of type C virus production and halt in immunoglobulin secretion by murine myeloma cells was studied. Employing two variants of the murine myeloma MOPC-315, immunoglobulin A-producing and nonproducing cells, we demonstrated that the two myelomas release similar levels of type C viruses which share common nucleotide sequences and that the viral genomes are equally expressed within the cells. Thus, the suggested relation between these two activities does not apply for MOPC-315 cells and probably for other murine myelomas also.

摘要

对C型病毒产生的停止与小鼠骨髓瘤细胞免疫球蛋白分泌停止之间的疑似相关性进行了研究。利用小鼠骨髓瘤MOPC - 315的两种变体，即产生免疫球蛋白A的细胞和不产生免疫球蛋白A的细胞，我们证明这两种骨髓瘤释放相似水平的C型病毒，这些病毒具有共同的核苷酸序列，并且病毒基因组在细胞内的表达水平相同。因此，这两种活动之间的推测关系不适用于MOPC - 315细胞，可能也不适用于其他小鼠骨髓瘤细胞。

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