Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.
Brain Tumor Pathol. 2012 Jul;29(3):140-7. doi: 10.1007/s10014-012-0104-2. Epub 2012 May 31.
To investigate whether grade II oligodendroglioma was transformed to glioblastoma or not, histopathological evaluation of recurrent oligodendrogliomal tumors (OG) and diffuse astrocytomas (DA) was performed. The OG group was composed of ten patients with OG, including seven oligodendrogliomas and three oligoastrocytomas. The DA group was composed of ten patients with DA, including eight fibrillary astrocytomas and two gemistocytic astrocytomas. The histopathological parameters of glioblastoma including nuclear atypia, multinucleated giant cells, glomeruloid tufts (GT) as a marker of microvascular proliferation, necrosis, and the Ki-67 staining index were investigated. Evaluation of these parameters was scored as follows: 0, none; 1, sporadic; 2, partial; 3, extensive. There were no cases of transformation to glioblastoma in the OG group. There were five cases of transformation to secondary glioblastoma in the DA group. In recurrent tumors, scores of GT and necrosis in the OG group were significantly lower than those in the DA group (p < 0.005). Nuclear atypia and high proliferative activity (Ki-67 index) were identified in recurrent tumors of the OG group. Our study suggested that the extent of GT and necrosis in recurrent OG was less than that in recurrent DA, and transformation to glioblastoma from oligodendroglial tumor was exceptional.
为了研究二级少突胶质细胞瘤是否转化为胶质母细胞瘤，对复发性少突胶质细胞瘤（OG）和弥漫性星形细胞瘤（DA）进行了组织病理学评估。OG 组由 10 名 OG 患者组成，包括 7 名少突胶质细胞瘤和 3 名少突星形细胞瘤。DA 组由 10 名 DA 患者组成，包括 8 名纤维状星形细胞瘤和 2 名胶质细胞瘤。研究了胶质母细胞瘤的核异型性、多核巨细胞、肾小球样簇（GT）作为微血管增殖的标志物、坏死和 Ki-67 染色指数等组织病理学参数。这些参数的评估评分如下：0，无；1，散在；2，部分；3，广泛。OG 组无一例转化为胶质母细胞瘤。DA 组有 5 例转化为继发性胶质母细胞瘤。在复发性肿瘤中，OG 组的 GT 和坏死评分明显低于 DA 组（p<0.005）。OG 组复发性肿瘤中存在核异型性和高增殖活性（Ki-67 指数）。本研究表明，复发性 OG 中的 GT 和坏死程度低于复发性 DA，从少突胶质细胞瘤转化为胶质母细胞瘤是例外的。
