产前基因治疗的概念。

The concept of prenatal gene therapy.

作者信息

Coutelle Charles, Waddington Simon N

机构信息

National Heart and Lung Institute, Molecular and Cellular Medicine Section, Imperial College London, London, UK.

出版信息

Methods Mol Biol. 2012;891:1-7. doi: 10.1007/978-1-61779-873-3_1.

DOI:10.1007/978-1-61779-873-3_1

PMID:22648765

Abstract

This introductory chapter provides a short review of the ideas and practical approaches that have led to the present and perceived future development of prenatal gene therapy. It summarizes the advantages and the potential adverse effects of this novel preventive and therapeutic approach to the management of prenatal diseases. It also provides guidance to the range of conditions to which prenatal gene therapy may be applied and to the technical approaches, vectors, and societal/ethical considerations for this newly emerging field of Fetal Medicine.

摘要

本章引言部分简要回顾了促成产前基因治疗当前及预期未来发展的理念和实际方法。总结了这种用于管理产前疾病的新型预防和治疗方法的优势及潜在不良影响。还针对产前基因治疗可能适用的一系列病症、技术方法、载体以及这一新兴胎儿医学领域的社会/伦理考量提供了指导。