用于产前基因治疗的载体系统：针对不同应用选择载体

Vector systems for prenatal gene therapy: choosing vectors for different applications.

作者信息

Coutelle Charles, Waddington Simon N

机构信息

National Heart and Lung Institute, Molecular and Cellular Medicine Section, Imperial College London, London, UK.

出版信息

Methods Mol Biol. 2012;891:41-53. doi: 10.1007/978-1-61779-873-3_3.

DOI:10.1007/978-1-61779-873-3_3

PMID:22648767

Abstract

This chapter gives a comparative review of the different vector systems applied to date in prenatal gene therapy experiments highlighting the need for versatility and choice for application in accordance with the actual aim of the study. It reviews the key characteristics of the four main gene therapy vector systems and gives examples for their successful application in prenatal gene therapy experiments.

摘要

本章对迄今为止在产前基因治疗实验中应用的不同载体系统进行了比较综述，强调了根据研究的实际目标需要通用性和应用选择。它回顾了四种主要基因治疗载体系统的关键特性，并给出了它们在产前基因治疗实验中成功应用的例子。