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RUNX3 is expressed in the epithelium of the gastrointestinal tract.

作者信息

Ito Yoshiaki

出版信息

EMBO Mol Med. 2012 Jul;4(7):541-2; author reply 543-4. doi: 10.1002/emmm.201100203. Epub 2012 May 31.

DOI:10.1002/emmm.201100203
PMID:22648993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3407940/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ac0/3407940/947bb5cbbe27/emmm0004-0541-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ac0/3407940/21f5c0556270/emmm0004-0541-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ac0/3407940/947bb5cbbe27/emmm0004-0541-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ac0/3407940/21f5c0556270/emmm0004-0541-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ac0/3407940/947bb5cbbe27/emmm0004-0541-f2.jpg

相似文献

1
RUNX3 is expressed in the epithelium of the gastrointestinal tract.RUNX3在胃肠道上皮中表达。
EMBO Mol Med. 2012 Jul;4(7):541-2; author reply 543-4. doi: 10.1002/emmm.201100203. Epub 2012 May 31.
2
Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function.正常胃肠道上皮中 Runx3 表达缺失使其抑癌功能受到质疑。
EMBO Mol Med. 2011 Oct;3(10):593-604. doi: 10.1002/emmm.201100168. Epub 2011 Aug 8.
3
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis.在经历转化生长因子β诱导凋亡的胃上皮细胞中，RUNX3肿瘤抑制因子上调Bim的表达。
Mol Cell Biol. 2006 Jun;26(12):4474-88. doi: 10.1128/MCB.01926-05.
4
Loss of Runx3 is a key event in inducing precancerous state of the stomach.Runx3 的缺失是诱导胃部癌前状态的关键事件。
Gastroenterology. 2011 May;140(5):1536-46.e8. doi: 10.1053/j.gastro.2011.01.043. Epub 2011 Jan 27.
5
Causal relationship between the loss of RUNX3 expression and gastric cancer.RUNX3表达缺失与胃癌之间的因果关系。
Cell. 2002 Apr 5;109(1):113-24. doi: 10.1016/s0092-8674(02)00690-6.
6
RUNX3 in oncogenic and anti-oncogenic signaling in gastrointestinal cancers.RUNX3 在胃肠癌中的致癌和抑癌信号转导。
J Cell Biochem. 2011 May;112(5):1243-9. doi: 10.1002/jcb.23047.
7
Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm.幽门螺杆菌感染导致胃肿瘤抑制因子 RUNX3 磷酸化，从而使其定位到细胞质中。
J Cell Physiol. 2012 Mar;227(3):1071-80. doi: 10.1002/jcp.22820.
8
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.RUNX3通过与转化生长因子β激活的SMAD协同诱导p21（WAF1/Cip1）表达来抑制胃上皮细胞生长。
Mol Cell Biol. 2005 Sep;25(18):8097-107. doi: 10.1128/MCB.25.18.8097-8107.2005.
9
Runx3 expression in gastrointestinal tract epithelium: resolving the controversy.Runx3在胃肠道上皮中的表达：解决争议
Oncogene. 2009 Mar 12;28(10):1379-84. doi: 10.1038/onc.2008.496. Epub 2009 Jan 26.
10
Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation.幽门螺杆菌 CagA 通过蛋白酶体介导的降解作用靶向胃肿瘤抑制因子 RUNX3。
Oncogene. 2010 Oct 14;29(41):5643-50. doi: 10.1038/onc.2010.304. Epub 2010 Aug 2.

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From inflammatory bowel disease to colorectal cancer: what's the role of miRNAs?从炎症性肠病到结直肠癌：微小RNA起什么作用？
Cancer Cell Int. 2022 Apr 11;22(1):146. doi: 10.1186/s12935-022-02557-3.

本文引用的文献

1
Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function.正常胃肠道上皮中 Runx3 表达缺失使其抑癌功能受到质疑。
EMBO Mol Med. 2011 Oct;3(10):593-604. doi: 10.1002/emmm.201100168. Epub 2011 Aug 8.
2
Runx3-deficient mouse strains circa 2008: resemblance and dissimilarity.2008年左右的Runx3基因缺陷小鼠品系：相似性与差异性。
Blood Cells Mol Dis. 2009 Jul-Aug;43(1):1-5. doi: 10.1016/j.bcmd.2009.01.009. Epub 2009 Feb 23.
3
Runx3 expression in gastrointestinal tract epithelium: resolving the controversy.
Runx3在胃肠道上皮中的表达：解决争议
Oncogene. 2009 Mar 12;28(10):1379-84. doi: 10.1038/onc.2008.496. Epub 2009 Jan 26.
4
RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization.RUNX3是一种新型肿瘤抑制因子，在胃癌中常因蛋白质定位错误而失活。
Cancer Res. 2005 Sep 1;65(17):7743-50. doi: 10.1158/0008-5472.CAN-05-0743.
5
Runx3 is involved in hair shape determination.Runx3参与毛发形状的决定。
Dev Dyn. 2005 Aug;233(4):1478-87. doi: 10.1002/dvdy.20453.
6
Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation.Runx3调节小鼠转化生长因子β介导的树突状细胞功能，其缺失会导致气道炎症。
EMBO J. 2004 Feb 25;23(4):969-79. doi: 10.1038/sj.emboj.7600085. Epub 2004 Feb 5.
7
Runx3 knockouts and stomach cancer.Runx3基因敲除与胃癌
EMBO Rep. 2003 Jun;4(6):560-4. doi: 10.1038/sj.embor.embor868.
8
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons.Runx3转录因子调节TrkC背根神经节神经元的发育和存活。
EMBO J. 2002 Jul 1;21(13):3454-63. doi: 10.1093/emboj/cdf370.
9
Causal relationship between the loss of RUNX3 expression and gastric cancer.RUNX3表达缺失与胃癌之间的因果关系。
Cell. 2002 Apr 5;109(1):113-24. doi: 10.1016/s0092-8674(02)00690-6.
10
Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis.Runx3（Aml2）和Runx1（Aml1）的时空表达模式表明其在小鼠胚胎发育过程中具有非冗余功能。
Mech Dev. 2001 Dec;109(2):413-7. doi: 10.1016/s0925-4773(01)00537-8.