乌干达坎帕拉穆拉戈医院患先兆子痫孕妇的血浆维生素C浓度
Plasma vitamin C concentration in pregnant women with pre-eclampsia in Mulago hospital, Kampala, Uganda.
作者信息
Kiondo P, Welishe G, Wandabwa J, Wamuyu-Maina G, Bimenya G S, Okong P
机构信息
Department of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda.
出版信息
Afr Health Sci. 2011 Dec;11(4):566-72.
BACKGROUND
Oxidative stress plays a role in the aetiology of pre-eclampsia and vitamin C may prevent pre-eclampsia.
OBJECTIVE
To determine the association between plasma vitamin C and pre-eclampsia in Mulago Hospital, Kampala, Uganda.
METHODS
This case-control study was conducted at Mulago Hospital from 1(st) May 2008 to 1(st) May 2009; 207 women were the cases and 352 women were the controls. Plasma vitamin C was assayed in the women using a colorimetric method. An independent t test was used to find the difference in the means of plasma vitamin C and logistic regression was used to find the association between plasma vitamin C and pre-eclampsia.
RESULTS
The mean plasma vitamin C was 1.7(SD=0.7) × 10(3) µg/L in women with pre-eclampsia and 1.9(SD=0.7) × 10(3) µg/L in women with normal pregnancy (P=0.005). Women with low plasma vitamin C were at an increased risk of pre-eclampsia (OR 2.91, 95% CI: 1.56-5.44).
CONCLUSION
There was a strong association between low plasma vitamin C, and pre-eclampsia in women attending antenatal clinics at Mulago Hospital, Kampala. Health workers need to advise women at risk in the antenatal period about diet, especially foods which are rich in vitamin C to probably reduce pre-eclampsia.
背景
氧化应激在子痫前期的病因学中起作用，维生素C可能预防子痫前期。
目的
确定乌干达坎帕拉穆拉戈医院血浆维生素C与子痫前期之间的关联。
方法
本病例对照研究于2008年5月1日至2009年5月1日在穆拉戈医院进行；207名女性为病例组，352名女性为对照组。采用比色法测定女性血浆维生素C水平。使用独立t检验找出血浆维生素C均值的差异，并使用逻辑回归分析找出血浆维生素C与子痫前期之间的关联。
结果
子痫前期女性的血浆维生素C平均水平为1.7（标准差=0.7）×10³μg/L，正常妊娠女性为1.9（标准差=0.7）×10³μg/L（P=0.005）。血浆维生素C水平低的女性患子痫前期的风险增加（比值比2.91，95%可信区间：1.56-5.44）。
结论
坎帕拉穆拉戈医院产前门诊女性中，血浆维生素C水平低与子痫前期之间存在密切关联。卫生工作者需要在孕期向有风险的女性提供饮食建议，尤其是富含维生素C的食物，以可能降低子痫前期的发生。
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