Pietrek Christian, Popov Tzvetan, Steffen Astrid, Miller Gregory A, Rockstroh Brigitte
Department of Psychology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany.
Depress Res Treat. 2012;2012:156529. doi: 10.1155/2012/156529. Epub 2012 May 10.
Dysfunctional emotion regulation is often reported in affective disorders, but it is unclear whether this dysfunction concerns initial processing of emotional input or regulation of resulting emotion. The present study addressed these aspects in 27 depressive and 15 borderline personality disorder patients and 28 healthy controls who were instructed to either passively view unpleasant and neutral pictures or downregulate emotional responses by reappraisal, while neuromagnetic brain activity was measured. All three groups showed more early response to unpleasant than to neutral pictures, whereas patients failed to show subsequent activity suppression under instructions to down-regulate. This deficient emotion regulation was evident primarily in those subjects reporting high childhood adversity. Results support intact emotional input processing but impaired emotion regulation in affective disorders and indicate a moderating influence of early life stress.
情感障碍中常出现功能失调的情绪调节，但尚不清楚这种功能失调是涉及情绪输入的初始处理还是对产生的情绪的调节。本研究针对27名抑郁症患者、15名边缘性人格障碍患者和28名健康对照者，让他们要么被动观看不愉快和中性的图片，要么通过重新评估来下调情绪反应，同时测量神经磁脑活动。所有三组对不愉快图片的早期反应均比对中性图片的反应更强，而患者在接到下调指令后未能表现出随后的活动抑制。这种情绪调节缺陷主要在那些报告童年有高度逆境的受试者中明显。结果支持情感障碍中情绪输入处理完好但情绪调节受损，并表明早期生活压力有调节作用。
