Risse S C, Lampe T H, Bird T D, Nochlin D, Sumi S M, Keenan T, Cubberley L, Peskind E, Raskind M A
Psychiatry Service, American Lake Veterans Administration Medical Center, Tacoma, Washington 98493.
Alzheimer Dis Assoc Disord. 1990 Winter;4(4):217-25. doi: 10.1097/00002093-199040400-00003.
Twenty-eight patients with the clinical diagnosis of probable Alzheimer disease (AD) were followed longitudinally until death. The presence of myoclonus, seizures, and paratonia was monitored as part of this process. At autopsy, 22 of the patients met pathologic criteria for AD and 6 had other degenerative neurologic diseases. Myoclonus was present in 55% of the AD patients and none of the non-AD patients. Seizures were present in 64% of the AD patients, and only 17% of the non-AD patients. Paratonia was found frequently in all patient groups. In most patients, symptoms developed late in the course of their illness. The incidence of myoclonus, seizures, and paratonia in our patients was higher than in most previous studies. The reasons for this finding are discussed.
28例临床诊断为可能的阿尔茨海默病（AD）的患者被纵向随访直至死亡。在此过程中，监测肌阵挛、癫痫发作和僵住症的存在情况。尸检时，22例患者符合AD的病理标准，6例患有其他退行性神经系统疾病。55%的AD患者存在肌阵挛，非AD患者均无肌阵挛。64%的AD患者出现癫痫发作，非AD患者仅17%出现癫痫发作。所有患者组中均频繁发现僵住症。在大多数患者中，症状在病程后期出现。我们患者中肌阵挛、癫痫发作和僵住症的发生率高于大多数先前的研究。本文讨论了这一发现的原因。
