Gao Xia, Zhang Jianying, Ma Benxu, Liu Lili, Gao Huanmin
Department of Neurology, Affiliated Hospital of Qingdao Binhai University, Qingdao, Shandong, China.
Department of Acupuncture, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao, Shandong, China.
Med Acupunct. 2024 Jun 21;36(3):146-154. doi: 10.1089/acu.2023.0076. eCollection 2024 Jun.
Parkinson's disease (PD) is a neurodegenerative disease affecting middle-age and elderly people. Its clinical manifestations include a series of progressive motor and nonmotor symptoms (NMS). Autonomic nervous dysfunction is a kind of NMS that includes constipation, hyperhidrosis, seborrheic dermatitis (sebaceous surface), salivation, sexual dysfunction, voiding dysfunction, and orthostatic hypotension. The incidence of autonomic nervous dysfunction is high, and the clinical manifestations are complex and changeable. It can occur before motor symptoms emerge, is closely related to the prognosis of PD, and affects quality of life seriously. Routine anti-PD drugs have little effect on improving autonomic nervous dysfunctions. Acupuncture for autonomic nervous dysfunction in PD induces a certain effect without adverse reactions, with potential advantages and broad prospects for application. This article summarizes and discusses the pathogenesis of autonomic nerve dysfunction in PD and acupuncture therapy for the condition to serve as a reference for clinical research.
帕金森病(PD)是一种影响中老年人的神经退行性疾病。其临床表现包括一系列进行性运动和非运动症状(NMS)。自主神经功能障碍是一种NMS,包括便秘、多汗、脂溢性皮炎(皮脂腺方面)、流涎、性功能障碍、排尿功能障碍和体位性低血压。自主神经功能障碍的发生率很高,临床表现复杂多变。它可在运动症状出现之前发生,与PD的预后密切相关,严重影响生活质量。常规抗PD药物对改善自主神经功能障碍作用不大。针刺治疗PD自主神经功能障碍有一定疗效且无不良反应,具有潜在优势和广阔的应用前景。本文对PD自主神经功能障碍的发病机制及针刺治疗进行总结和探讨,以供临床研究参考。