Zhang Ying, Chen Hongmei, Wu Xinyi
Department of Ophthalmology, Qilu Hospital, Shandong University, China.
Ophthalmic Epidemiol. 2012 Aug;19(4):226-30. doi: 10.3109/09286586.2012.670742. Epub 2012 May 31.
To determine the prevalence and risk factors for dry eye syndrome (DES) among senior high school students in Shouguang, a county of Shandong Province, China.
A cross-sectional survey was conducted in July 2010, and 1902 senior high school students were selected by multi-stage sampling to answer a questionnaire assessing the prevalence and risk factors for DES. DES was defined as the presence of a previous clinical diagnosis of DES or severe symptoms (both dryness and irritation constantly or often). Risk factors associated with DES were evaluated with a χ(2) test and logistic regression analyses.
The prevalence of DES was 23.7%. In univariate analysis, myopia (P < 0.0001), contact lens wear (P = 0.020), inadequate refractive correction (P < 0.0001), frequent self-administered topical ophthalmic medications (P < 0.0001), and poor sleep quality (P = 0.007) were significantly associated with DES. In multivariate analysis, inadequate refractive correction (P < 0.0001, odds ratio, OR 1.980; 95% confidence interval, CI 1.577-2.488), frequent self-administered topical ophthalmic medications (P < 0.0001, OR 1.838; 95% CI 1.399-2.410), and poor sleep quality (P = 0.001, OR 1.342; 95% CI 1.054-1.709) were significant risk factors for DES.
Senior high school students are a neglected population with a high prevalence of DES. Preventive measures directed against risks factors for DES among senior high school students may help reduce the prevalence and provide a positive impact on students' health.
确定中国山东省寿光市高中生干眼综合征(DES)的患病率及危险因素。
于2010年7月进行横断面调查,通过多阶段抽样选取1902名高中生,回答一份评估DES患病率及危险因素的问卷。DES定义为既往有DES临床诊断或有严重症状(持续或经常出现眼干和眼刺激感)。采用χ(2)检验和逻辑回归分析评估与DES相关的危险因素。
DES患病率为23.7%。单因素分析显示,近视(P<0.0001)、佩戴隐形眼镜(P = 0.020)、屈光矫正不足(P<0.0001)、频繁自行使用局部眼科药物(P<0.0001)及睡眠质量差(P = 0.007)与DES显著相关。多因素分析显示,屈光矫正不足(P<0.0001,比值比,OR 1.980;95%置信区间,CI 1.577 - 2.488)、频繁自行使用局部眼科药物(P<0.0001,OR 1.838;95% CI 1.399 - 2.410)及睡眠质量差(P = 0.001,OR 1.342;95% CI 1.054 - 1.709)是DES的显著危险因素。
高中生是DES患病率较高但被忽视的人群。针对高中生DES危险因素采取预防措施可能有助于降低患病率,并对学生健康产生积极影响。