Neuroscience Research Australia and the University of New South Wales, Barker Street, Randwick 2031, Sydney, NSW, Australia.
Expert Rev Neurother. 2012 Jun;12(6):673-86. doi: 10.1586/ern.12.47.
Braak's proposal that, in patients with Parkinson's disease, Lewy bodies and neurites progressively invade the brain through regions connected to autonomic and olfactory centers remains contentious. Confounding factors include the lack of an in vivo marker to examine the progression of Lewy pathology, the retrospective nature or absence of clinical information for many cross-sectional pathological datasets, and for those with limited disease (clinically or neuropathologically), the absence of information concerning additional conditions. Despite these data limitations at this time, the brain pathology for most patients with typical Parkinson's disease can be predicted using Braak's scheme. What this tells us about the pathogenesis of Parkinson's disease will be explored in this review.
布拉克（Braak）提出，在帕金森病患者中，路易体和神经突通过与自主神经和嗅觉中枢相连的区域逐渐侵入大脑，这一观点仍存在争议。混淆因素包括缺乏活体标志物来检查路易体病理的进展，许多横断面病理数据集缺乏临床信息或为回顾性研究，对于那些疾病（临床或神经病理学上）有限的患者，缺乏有关其他情况的信息。尽管目前存在这些数据限制，但使用布拉克（Braak）方案可以预测大多数典型帕金森病患者的脑病理。在本综述中，我们将探讨这一方案对帕金森病发病机制的启示。
