Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
Org Lett. 2012 Jun 15;14(12):3072-5. doi: 10.1021/ol3011425. Epub 2012 May 31.
The building block synthesis of a derivative of CB[6] that bears a reactive propargyloxy group and its functionalization by click chemistry to yield 1 which contains a covalently attached isobutylammonium group is presented. Compound 1 undergoes self-assembly to yield a cyclic [c2] daisy chain assembly (1(2)) in water. The behavior of 1(2) in response to various stimuli (e.g., guests and CB[n] receptors) is described.
介绍了一种衍生的 CB[6] 砌块的合成，该砌块带有反应性炔丙氧基基团，并通过点击化学官能化得到 1，其中含有共价连接的异丁基铵基团。化合物 1 自组装生成环[C2]雏菊链组装体（1(2)）在水中。描述了 1(2) 对各种刺激（例如客体和 CB[n]受体）的响应行为。
