Sheehan-Dare R A, Henderson M J, Cotterill J A
Department of Dermatology, General Infirmary, Leeds, U.K.
Br J Dermatol. 1990 Dec;123(6):769-74. doi: 10.1111/j.1365-2133.1990.tb04195.x.
Thirty-four dermatology out-patients with chronic idiopathic urticaria and 34 with idiopathic generalized pruritus were investigated using standardized self-assessment psychological questionnaires to determine the incidence of significant symptoms of depression and anxiety. These patients were compared with age- and sex-matched but otherwise unselected general dermatology out-patients. Using the Beck depression inventory, significantly more patients with generalized pruritus (32.4%) had depressive symptomatology (score greater than 14) than controls (13.2%, P less than 0.05). Although more patients with chronic urticaria had depressive symptomatology (14.7%) than controls (4.4%), the difference was not statistically significant. Using the Speilberger state-trait anxiety inventory there were no significant differences between the patients with pruritus or urticaria and their controls with respect to state or trait anxiety scores above the upper 90% probability limit for the general population. Thus, significant depression may be expected in a substantial proportion of patients with idiopathic generalized pruritus but in a relatively small proportion of those with chronic urticaria.
采用标准化的自我评估心理问卷，对34例慢性特发性荨麻疹门诊患者和34例特发性全身性瘙痒患者进行调查，以确定抑郁和焦虑显著症状的发生率。将这些患者与年龄、性别匹配但未作其他选择的普通皮肤科门诊患者进行比较。使用贝克抑郁量表，全身性瘙痒患者中有显著更多比例（32.4%）出现抑郁症状（得分高于14分），高于对照组（13.2%，P<0.05）。虽然慢性荨麻疹患者出现抑郁症状的比例（14.7%）高于对照组（4.4%），但差异无统计学意义。使用斯皮尔伯格状态-特质焦虑量表，瘙痒或荨麻疹患者与其对照组在状态或特质焦虑得分方面，高于一般人群90%概率上限的部分无显著差异。因此，特发性全身性瘙痒患者中相当大比例可能存在显著抑郁，而慢性荨麻疹患者中该比例相对较小。
