Walker F O, Lewis S F
Department of Neurology, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
Reg Anesth. 1990 Mar-Apr;15(2):61-6.
As a topical agent, capsaicin reportedly blocks pain without otherwise impairing sensation. Ten subjects underwent blinded, multiple-dose application of topical 0.025% capsaicin or control emollient to skin test sites in order to evaluate capsaicin effectiveness and toxicity. Clinical changes in somesthetic perception of pinprick, heat and cold developed, but neurogenic flare responses were unchanged. Clinical and electrophysiologic measures of large fiber and autonomic function were unaffected by capsaicin. This study indicates that 0.025% capsaicin is a safe topical agent with demonstrable clinical effects on small fiber function but not on large fiber or autonomic function.
据报道，辣椒素作为一种局部用药，可阻断疼痛，而不会损害其他感觉。为了评估辣椒素的有效性和毒性，10名受试者在皮肤测试部位接受了局部0.025%辣椒素或对照润肤剂的双盲、多剂量应用。针刺、热觉和冷觉的躯体感觉知觉出现了临床变化，但神经源性潮红反应未改变。辣椒素对大纤维和自主神经功能的临床及电生理测量指标没有影响。这项研究表明，0.025%辣椒素是一种安全的局部用药，对小纤维功能有明显临床效果，但对大纤维或自主神经功能无影响。
