Pasero Chris, Stannard Daphne
Pain Manag Nurs. 2012 Jun;13(2):107-24. doi: 10.1016/j.pmn.2012.03.002.
For more than a century, acetaminophen has been recognized worldwide as a safe and effective agent for relieving pain and reducing fever in a wide range of patients. However, until recently, acetaminophen was available in the United States only in oral and rectal suppository formulations. In November 2010, the United States Food and Drug Administration granted approval for the use of a new intravenous (IV) formulation of acetaminophen for: 1) the management of mild to moderate pain; 2) the management of moderate to severe pain with adjunctive opioid analgesics; and 3) the reduction of fever in adults and children (age ≥ 2 years). This case-illustrated review of IV acetaminophen begins with a discussion of the rationale for the drug's development and proceeds to analyze the clinical pharmacology, efficacy, safety, and nursing implications of its use, both as monotherapy and in combination with other agents as part of a multimodal pain therapy strategy.
一个多世纪以来，对乙酰氨基酚在全球范围内被公认为是一种安全有效的药物，可用于缓解各类患者的疼痛和降低体温。然而，直到最近，对乙酰氨基酚在美国仅以口服和直肠栓剂剂型供应。2010年11月，美国食品药品监督管理局批准使用一种新的对乙酰氨基酚静脉注射（IV）剂型，用于：1）管理轻至中度疼痛；2）与辅助性阿片类镇痛药联合管理中至重度疼痛；3）降低成人和儿童（年龄≥2岁）的体温。本病例说明性综述从讨论该药物的研发原理开始，接着分析其作为单一疗法以及作为多模式疼痛治疗策略的一部分与其他药物联合使用时的临床药理学、疗效、安全性及护理注意事项。
