Department of Urology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
Sci Rep. 2021 Mar 4;11(1):5174. doi: 10.1038/s41598-021-84866-7.
The objective of this study was to examine the impact of around-the-clock (ATC) administration of intravenous (IV) acetaminophen following robot-assisted radical prostatectomy (RARP). Intravenous infusion of acetaminophen was started on the day of the operation at 1000 mg/dose every 6 h, and the infusion was continued on a fixed schedule until postoperative day 2 a.m. In a retrospective observational study, we compared 127 patients who were administered IV acetaminophen on a fixed schedule (ATC group) with 485 patients who were administered analgesic drugs only as needed (PRN group). We investigated postoperative pain intensity and additional analgesic consumption on postoperative day 0, 1, 2, 3, and 5 between the two groups. Postoperative pain scores were significantly lower in the ATC group than in the PRN group at 1 and 2 days, and this period matched the duration of ATC administration of IV acetaminophen. Postoperative frequency of rescue analgesia was significantly lower in the ATC group than in the PRN group at postoperative 0, 1, and 2 days. ATC administration of IV acetaminophen has the potential to be a very versatile and valuable additional dose to achieve appropriate postoperative analgesia in patients with RARP.
本研究旨在探讨机器人辅助前列腺根治性切除术（RARP）后 24 小时静脉（IV）给予对乙酰氨基酚的影响。术后当日，每 6 小时给予 1000mg/剂的 IV 对乙酰氨基酚，固定方案持续输注至术后第 2 天上午 2 点。在一项回顾性观察研究中，我们比较了 127 例按固定方案（ATC 组）给予 IV 对乙酰氨基酚的患者和 485 例仅按需给予镇痛药物的患者（PRN 组）。我们比较了两组患者在术后第 0、1、2、3 和 5 天的术后疼痛强度和额外镇痛药物消耗。术后第 1 和第 2 天，ATC 组的术后疼痛评分明显低于 PRN 组，且这段时间与 IV 对乙酰氨基酚的 ATC 给药时间相吻合。术后第 0、1 和第 2 天，ATC 组的术后解救镇痛频率明显低于 PRN 组。ATC 给予 IV 对乙酰氨基酚可能是一种非常通用且有价值的额外剂量，可使接受 RARP 的患者获得适当的术后镇痛。
