Yu Nicole Y C, Schindeler Aaron, Tagil Magnus, Ruys Andrew J, Little David G
Department of Orthopaedic Research and Biotechnology, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia.
Front Biosci (Elite Ed). 2012 Jun 1;4(7):2647-53. doi: 10.2741/e572.
In orthopaedics, focus is often placed on increasing bone formation by an anabolic drug like the recombinant human bone morphogenetic protein (rhBMP). However, premature or excessive bone resorption, due to stress-shielding, instability or infection/inflammation can lead to poor, delayed, or absent bone union. Anti-catabolic drugs such as bisphosphonates have therefore been explored to improve bone repair. This short review discusses the current literature underlying the anabolic-catabolic paradigm for bone repair with a focus on BMP and bisphosphonate combination approaches.
在骨科领域，人们常常聚焦于通过重组人骨形态发生蛋白（rhBMP）等促合成药物来增加骨形成。然而，由于应力遮挡、不稳定或感染/炎症导致的过早或过度骨吸收，可能会导致骨愈合不良、延迟或不愈合。因此，人们探索了双膦酸盐等抗分解代谢药物来改善骨修复。这篇简短的综述讨论了当前关于骨修复的合成代谢-分解代谢范式的文献，重点关注BMP和双膦酸盐联合应用的方法。
