Division of Gastroenterology and Hepatology, The First Hospital of Lanzhou University, Lazhou, Gansu Province, China.
Front Biosci (Landmark Ed). 2012 Jun 1;17(7):2383-90. doi: 10.2741/4059.
Obesity is an important public health problem worldwide. It increases the risk of many chronic diseases such as diabetes and cardiovascular diseases. Meanwhile, obesity is a major risk factor for several types of cancer including gastric cancer. Possible mechanisms linking obesity with gastric cancer may include obesity associated gastro-oesophageal reflux, insulin resistance, altered levels of adiponectin, leptin, ghrelin, and an abnormally increased blood level of insulin-like growth factor (IGF). Helicobacter pylori (H. pylori) infection is a well-recognized risk factor for peptic ulcer and gastric cancer. Recent studies have revealed an increased prevalence of H. pylori infection in obese patients, providing another clue for the increased incidence of gastric cancer in obese population. If this connection can be confirmed in animal models and a large cohort of patients, then eradicating H. pylori together with life style modification in obese individuals may help prevent the development of gastric cancer in the increasingly obese population.
肥胖是一个全球性的重要公共卫生问题。它增加了患许多慢性疾病的风险，如糖尿病和心血管疾病。同时，肥胖也是多种癌症的主要危险因素，包括胃癌。肥胖与胃癌之间可能存在的联系机制包括肥胖相关的胃食管反流、胰岛素抵抗、脂联素、瘦素、胃饥饿素水平改变以及异常升高的胰岛素样生长因子 (IGF) 血水平。幽门螺杆菌 (H. pylori) 感染是消化性溃疡和胃癌的一个公认危险因素。最近的研究表明，肥胖患者的 H. pylori 感染率增加，这为肥胖人群中胃癌发病率的增加提供了另一个线索。如果这一关联能够在动物模型和大量患者中得到证实，那么在肥胖个体中同时消除 H. pylori 并改变生活方式可能有助于预防日益肥胖人群中胃癌的发生。
