Institute and Department of Endocrinology and Metabolism of Shanghai Ninth People's Hospital Affiliated Shanghai Jiaotong University School of Medicine, Shanghai, China.
Front Biosci (Landmark Ed). 2012 Jun 1;17(7):2391-5. doi: 10.2741/4060.
Insulin production by beta-cells derived from hepatic oval cells is a promising new approach for the treatment of diabetes. Hepatic oval cells can be redirected to the beta-cell linage by an appropriate combination of high extracellular glucose, specific extracellular matrix proteins (laminin and fibronectin), cytokines (activin A), and the expression of several differentiation-related transcription factors (Pdx-1, Ngn-3, MafA). We explore the process of hepatic oval cell transdifferentiation into pancreatic islet beta-cells and the cellular signaling pathways involved.
由肝卵圆细胞衍生的β细胞产生胰岛素是治疗糖尿病的一种很有前途的新方法。通过高细胞外葡萄糖、特定细胞外基质蛋白（层粘连蛋白和纤维连接蛋白）、细胞因子（激活素 A）和几种分化相关转录因子（Pdx-1、Ngn-3、MafA）的适当组合，可以将肝卵圆细胞重定向到β细胞谱系。我们探索了肝卵圆细胞向胰岛β细胞转化的过程以及涉及的细胞信号通路。
