Novel therapies, high-risk pediatric research, and the prospect of benefit: learning from the ethical disagreements.
作者信息
de Melo-Martín Inmaculada, Sondhi Dolan, Crystal Ronald G
机构信息
Division of Medical Ethics, Department of Public Health, Weill Cornell Medical College, New York, New York 10065, USA.
出版信息
Mol Ther. 2012 Jun;20(6):1095-102. doi: 10.1038/mt.2012.90.
Abstract
摘要
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本文引用的文献
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Clinical research. Gene therapists celebrate a decade of progress.临床研究。基因治疗专家庆祝取得十年进展。
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Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years.针对由RPE65基因突变引起的莱伯先天性黑蒙的基因治疗：15名儿童和成人的安全性和有效性，随访长达3年。
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Eschewing definitions of the therapeutic misconception: a family resemblance analysis.避开治疗性误解的定义：一种家族相似性分析
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Preclinical studies of human disease: time to take methodological quality seriously.人类疾病的临床前研究：是时候认真对待方法学质量了。
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Adverse drug reactions in newborns, infants and toddlers: pediatric pharmacovigilance between present and future.新生儿、婴儿和学步儿童的药物不良反应：现在与未来之间的儿科药物警戒。
Expert Opin Drug Saf. 2012 Jan;11(1):95-105. doi: 10.1517/14740338.2011.584531. Epub 2011 May 9.
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Does it matter whether investigators intend to benefit research subjects?研究者是否有意使研究对象受益重要吗？
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Harmonization of ethics policies in pediatric research.儿科研究伦理政策的协调统一。
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Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia.基因治疗人类β-地中海贫血后实现输血独立性和 HMGA2 激活。
Nature. 2010 Sep 16;467(7313):318-22. doi: 10.1038/nature09328.
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