el-Sherif A E, Foda R, Norlen L J, Yahia H
Department of Urology, Hamad General Hospital, Doha, Qatar.
Br J Urol. 1990 Dec;66(6):602-5. doi: 10.1111/j.1464-410x.1990.tb07190.x.
In a study of the pain-relieving effect of 3 drugs commonly used to treat acute renal colic in this hospital, intravenous indomethacin and intramuscular diclofenac (prostaglandin synthetase inhibitors) were compared with intravenous Avafortan (analgesic antispasmodic). As first-line analgesics, prostaglandin synthetase inhibitors, if given intravenously, offer an effective alternative to Avafortan. Of 145 patients studied, 32 required a second injection for complete relief of pain. Administering a second dose of prostaglandin synthetase inhibitors resulted in equally significant pain relief rate even though the route was intramuscular.
在一项关于本院常用的3种治疗急性肾绞痛药物的止痛效果的研究中，将静脉注射吲哚美辛和肌肉注射双氯芬酸（前列腺素合成酶抑制剂）与静脉注射阿法坦（止痛解痉药）进行了比较。作为一线镇痛药，前列腺素合成酶抑制剂若静脉给药，可作为阿法坦的有效替代药物。在145名研究患者中，32名患者需要第二次注射才能完全缓解疼痛。即使给药途径为肌肉注射，给予第二剂前列腺素合成酶抑制剂也能产生同样显著的止痛效果。
