Laerum E, Ommundsen O E, Grønseth J E, Christiansen A, Fagertun H E
Department of General Practice, University of Oslo, Norway.
Eur Urol. 1996;30(3):358-62. doi: 10.1159/000474196.
We have conducted a clinical trial to compare the pain-relieving effect and safety of diclofenac administered intramuscularly to indomethacin given intravenously.
The study was designed as a randomized single-blind trial. It was carried out at Oslo Emergency Hospital (outpatient setting or stay < 24 h). 41 patients with a mean age of 41.6 years received 75 mg diclofenac and 42 patients with a mean age of 45.2 years were given 50 mg indomethacin. The two groups were similar in regard to baseline characteristics except gender distribution.
Statistically significant reduction in pain intensity was achieved after 5 min in the diclofenac group (p < 0.01), and after 10 min in the indomethacin group (p < 0.01). The probability of having pain after 1 h was 52% in the indomethacin group and 37% in the diclofenac group (p = 0.11). Rescue medication with pethidine after 2 h was given in 9 and 5 patients, respectively. Four patients in the diclofenac group reported one occurrence of adverse effect each, while 9 patients on indomethacin experienced 14 occurrences, mainly dizziness and nausea.
These findings together with a simpler mode of administration indicate that diclofenac may be preferred in the analgesic treatment of renal colic.
我们进行了一项临床试验，以比较肌肉注射双氯芬酸与静脉注射吲哚美辛的止痛效果和安全性。
该研究设计为随机单盲试验。在奥斯陆急诊医院（门诊环境或住院时间<24小时）进行。41名平均年龄为41.6岁的患者接受了75毫克双氯芬酸，42名平均年龄为45.2岁的患者接受了50毫克吲哚美辛。除性别分布外，两组在基线特征方面相似。
双氯芬酸组在5分钟后疼痛强度有统计学意义的降低（p<0.01），吲哚美辛组在10分钟后疼痛强度有统计学意义的降低（p<0.01）。1小时后仍有疼痛的概率在吲哚美辛组为52%，在双氯芬酸组为37%（p = 0.11）。2小时后分别有9名和5名患者使用哌替啶进行解救用药。双氯芬酸组有4名患者各报告发生1次不良反应，而吲哚美辛组有9名患者发生14次不良反应，主要是头晕和恶心。
这些发现以及更简单的给药方式表明，在肾绞痛的止痛治疗中双氯芬酸可能更受青睐。
