Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
J Med Screen. 2012 Jun;19(2):94-102. doi: 10.1258/jms.2012.012016. Epub 2012 May 31.
To report participant recruitment experiences in a large, US randomized controlled trial (RCT) of lung cancer screening, with the aim of providing information that may be of use to researchers who wish to conduct similar future studies.
The National Lung Screening Trial (NLST), an RCT that demonstrated a 20% lung cancer mortality reduction with low dose helical computed tomography screening, relative to single-view chest radiograph screening. Thirty-three US medical centres recruited 53,454 participants from August 2002 through April 2004.
After recruitment was completed, centre co-ordinators were asked to complete a questionnaire addressing the extent to which specific methods were used and, for each specific method, numbers enrolled and total cost of the effort. Cost per enrollee was calculated. Co-ordinators also were asked to report lessons learned.
Twenty-two centres returned questionnaires. Use of recruitment method varied by centre. Among centres reporting number enrolled by method, about 19,000 participants were enrolled with direct mail, about 4200 with mass media, and about 1000 with community outreach. Cost per enrollee varied across centres but medians were (US) $101 (direct mail), $79 (mass media), and $4 (community outreach). Co-ordinators reported that it was important to know where to find persons likely to be eligible and interested, and how best to approach them.
Most NLST participants were recruited through direct mail, although median cost per participant was highest for that method.
报告在美国一项大型肺癌筛查随机对照试验（RCT）中的参与者招募经验，旨在为希望开展类似未来研究的研究人员提供有用的信息。
国家肺癌筛查试验（NLST）是一项 RCT，与单视图胸部 X 线筛查相比，低剂量螺旋 CT 筛查可使肺癌死亡率降低 20%。33 个美国医疗中心于 2002 年 8 月至 2004 年 4 月期间招募了 53454 名参与者。
招募完成后，中心协调员被要求填写一份问卷，内容涉及特定方法的使用程度，以及每种特定方法的入组人数和招募工作的总费用。计算了每位入组者的费用。协调员还被要求报告所吸取的经验教训。
22 个中心返回了问卷。各中心的招募方法各不相同。在报告按方法入组人数的中心中，大约有 19000 名参与者通过直邮入组，大约有 4200 名参与者通过大众媒体入组，大约有 1000 名参与者通过社区外展入组。各中心的每位入组者费用不同，但中位数分别为 101 美元（直邮）、79 美元（大众媒体）和 4 美元（社区外展）。协调员报告说，了解在哪里可以找到可能符合条件和有兴趣的人，以及如何最好地接触他们是很重要的。
大多数 NLST 参与者是通过直邮招募的，尽管每位参与者的平均费用最高。
