麻醉猫和大鼠中间外侧细胞柱中[3H]哌唑嗪结合以及离子导入甲氧明对交感神经节前神经元活动的影响。
[3H]prazosin binding in the intermediolateral cell column and the effects of iontophoresed methoxamine on sympathetic preganglionic neuronal activity in the anaesthetized cat and rat.
作者信息
Marks S A, Stein R D, Dashwood M R, Gilbey M P
机构信息
Department of Physiology, Royal Free Hospital School of Medicine, London, U.K.
出版信息
Brain Res. 1990 Oct 22;530(2):321-4. doi: 10.1016/0006-8993(90)91303-x.
The autoradiographic localization of [3H]prazosin (alpha 1-adrenoceptor ligand) binding sites was determined in cat spinal cord sections. High levels of [3H]prazosin binding were found in the intermediolateral cell column (IML) at thoracic and lumbar levels. The iontophoresis of the alpha 1-adrenoceptor agonist methoxamine onto sympathetic preganglionic neurones (SPNs) in anaesthetized cats and rats caused excitation of 8 cat SPNs and 13 rat SPNs. These results suggest an excitatory role for some of the catecholaminergic innervation of the IML.
在猫脊髓切片中确定了[3H]哌唑嗪（α1-肾上腺素能受体配体）结合位点的放射自显影定位。在胸段和腰段的中间外侧细胞柱（IML）中发现了高水平的[3H]哌唑嗪结合。在麻醉的猫和大鼠中，将α1-肾上腺素能受体激动剂甲氧明离子导入交感神经节前神经元（SPN），导致8只猫的SPN和13只大鼠的SPN兴奋。这些结果表明IML的一些儿茶酚胺能神经支配具有兴奋作用。
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