Dept. of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Eur Respir J. 2013 Feb;41(2):323-9. doi: 10.1183/09031936.00012112. Epub 2012 May 31.
Measures of body mass index (BMI) and waist circumference define general obesity and abdominal obesity respectively. While high BMI has been established as a risk factor for asthma in adults, waist circumference has seldom been investigated. To determine the association between BMI, waist circumference and incident asthma in adults, we conducted a prospective study (n=23,245) in a population living in Nord-Trøndelag, Norway in 1995-2008. Baseline BMI and waist circumference were measured and categorised as general obesity (BMI ≥30.0 kg·m(2)) and abdominal obesity (waist circumference ≥88 cm in females and ≥102 cm in males). Incident asthma was self-reported new-onset cases during an 11-yr follow-up period. Odds ratios for asthma associated with obesity were calculated using multivariable logistic regression. General obesity was a risk factor for asthma in females (OR 1.96, 95% CI 1.52-2.52) and males (OR 1.84, 95% CI 1.30-2.59). In females, after additional adjustment for BMI, abdominal obesity remained a risk factor for asthma development (OR 1.46, 95% CI 1.04-2.05). Abdominal obesity seems to increase the risk of incident asthma in females in addition to BMI, indicating that using both measures of BMI and waist circumference in females may be a superior clinical assessment for asthma risk than any measure alone.
体重指数（BMI）和腰围测量值分别定义了全身性肥胖和腹部肥胖。虽然高 BMI 已被确定为成人哮喘的一个风险因素，但腰围却很少被研究过。为了确定 BMI 和腰围与成年人哮喘发病的相关性，我们在 1995 年至 2008 年期间对生活在挪威诺尔兰北部的人群进行了一项前瞻性研究（n=23245）。在基线时测量了 BMI 和腰围，并将其分类为全身性肥胖（BMI≥30.0kg·m(2)）和腹部肥胖（女性腰围≥88cm，男性腰围≥102cm）。哮喘发病是在 11 年随访期间自我报告的新发病例。使用多变量逻辑回归计算肥胖与哮喘相关的比值比（OR）。在女性（OR 1.96，95%CI 1.52-2.52）和男性（OR 1.84，95%CI 1.30-2.59）中，全身性肥胖是哮喘的一个危险因素。在女性中，在对 BMI 进行额外调整后，腹部肥胖仍然是哮喘发病的一个危险因素（OR 1.46，95%CI 1.04-2.05）。腹部肥胖除 BMI 外似乎还增加了女性发生哮喘的风险，这表明在女性中使用 BMI 和腰围这两种测量方法可能比单独使用任何一种方法对哮喘风险的临床评估更优越。
