Zhu Hui-Fang, Zhang Yuan-Xu, Zhao Xu-Dong
Chinese Academy of Science, Kunming, China.
Dongwuxue Yanjiu. 2012 Jun;33(3):337-42. doi: 10.3724/SP.J.1141.2012.03337.
The glioma accounts for half of the central nervous tumors, among which the glioblastoma multiforme (GBM) is one of the most aggressive and lethal brain tumors. The difficulties in glioma therapy indicate the need of appropriate animal models for preclinical studies. Benefiting from the development of molecular biology, genetics, and transgenic technology, variable animal models of glioma have been established. These animal models of human glioma are reviewed in this paper.
胶质瘤占中枢神经系统肿瘤的一半，其中多形性胶质母细胞瘤（GBM）是最具侵袭性和致命性的脑肿瘤之一。胶质瘤治疗的困难表明需要合适的动物模型用于临床前研究。得益于分子生物学、遗传学和转基因技术的发展，已建立了多种胶质瘤动物模型。本文对这些人类胶质瘤动物模型进行综述。
