Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul 136-705, South Korea.
World J Gastroenterol. 2012 May 21;18(19):2377-82. doi: 10.3748/wjg.v18.i19.2377.
To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations.
The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology.
The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively).
There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients.
比较幽门螺杆菌（H. pylori）感染的序贯疗法与不同疗程三联疗法的疗效。
本研究纳入了 460 例患有 H. pylori 相关性胃炎或胃溃疡、十二指肠溃疡的患者。经过筛选，将 H. pylori 感染患者随机分为接受常规三联疗法（7、10 或 14 天）或新的 10 天序贯疗法的患者。每组治疗包括 115 例患者。治疗 4 周后通过尿素呼气试验和组织学评估根除治疗的结果。
总的根除率为 81.0%，7 天常规三联疗法的根除率为 75.7%，10 天常规三联疗法为 81.9%，14 天常规三联疗法为 84.4%，10 天序贯疗法为 82.0%。意向治疗分析和方案分析均未显示序贯疗法与标准三联疗法的根除率有显著差异（P=0.416 和 P=0.405）。
在韩国患者中，10 天的序贯根除疗法与任何疗程的标准三联治疗之间没有显著差异。
