Suppr超能文献

日本干眼症的年度直接成本。

Annual direct cost of dry eye in Japan.

作者信息

Mizuno Yoshinobu, Yamada Masakazu, Shigeyasu Chika

机构信息

Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan.

出版信息

Clin Ophthalmol. 2012;6:755-60. doi: 10.2147/OPTH.S30625. Epub 2012 May 16.

Abstract

BACKGROUND

This study was performed to estimate the annual direct cost incurred by dry eye patients, which includes expenses for treatment and drugs, as well as the cost of punctal plugs.

METHODS

The study group consisted of 118 dry eye patients aged 20 years or older who visited any of the 15 medical care facilities that participated in this prospective cohort dry eye study. We estimated annual direct costs from outpatient medical records and survey questionnaires obtained from patients.

RESULTS

Of the total patients enrolled, 10 were men and 108 women, and their average age was 64.1 ± 11.2 years. The number of hospital visits made by patients was 5.8 ± 3.6 per year. Among those who used ophthalmic solutions, the numbers of bottles used per year were as follows: 32.1 ± 20.8 bottles of hyaluronic acid ophthalmic solution (87 patients), 53.1 ± 42.2 bottles of artificial tears (40 patients), and 33.2 ± 23.2 bottles of over-the-counter eyedrops (15 patients). In patients with punctal plugs, 4.1 ± 3.9 plugs were used annually. The annual drug cost was 32,000 ± 21,675 Japanese yen (323 ± 219 US dollars). The clinical cost was 16,318 ± 9961 Japanese yen (165 ± 101 US dollars). The total direct costs including punctal plug treatment amounted to 52,467 ± 38,052 Japanese yen (530 ± 384 US dollars).

CONCLUSION

Although treatment modalities for dry eye in Japan were different from those in the US and in European countries, the direct cost of dry eye patients in Japan was comparable with that reported in those countries. Considering the high prevalence of dry eye, the direct cost of this chronic condition may be significant.

摘要

背景

本研究旨在估算干眼症患者每年产生的直接费用,其中包括治疗费用、药物费用以及泪点塞的费用。

方法

研究组由118名年龄在20岁及以上的干眼症患者组成,这些患者前往参与这项前瞻性队列干眼症研究的15家医疗机构中的任何一家就诊。我们根据门诊病历和患者调查问卷估算年度直接费用。

结果

在纳入的患者中,男性10名,女性108名,平均年龄为64.1±11.2岁。患者每年就诊次数为5.8±3.6次。在使用眼药水的患者中,每年使用的瓶数如下:透明质酸眼药水32.1±20.8瓶(87例患者),人工泪液53.1±42.2瓶(40例患者),非处方眼药水33.2±23.2瓶(15例患者)。使用泪点塞的患者每年使用4.1±3.9个泪点塞。年度药物费用为32,000±21,675日元(323±219美元)。临床费用为16,318±9961日元(165±101美元)。包括泪点塞治疗在内的总直接费用为52,467±38,052日元(530±384美元)。

结论

尽管日本干眼症的治疗方式与美国和欧洲国家不同,但日本干眼症患者的直接费用与这些国家报告的费用相当。考虑到干眼症的高患病率,这种慢性病的直接费用可能相当可观。

相似文献

1
Annual direct cost of dry eye in Japan.
Clin Ophthalmol. 2012;6:755-60. doi: 10.2147/OPTH.S30625. Epub 2012 May 16.
2
Punctal occlusion for dry eye syndrome.
Cochrane Database Syst Rev. 2017 Jun 26;6(6):CD006775. doi: 10.1002/14651858.CD006775.pub3.
3
Cost impact of COPD in Japan: opportunities and challenges?
Respirology. 2004 Nov;9(4):466-73. doi: 10.1111/j.1440-1843.2004.00617.x.
5
Efficacy and tolerability outcomes after punctal occlusion with silicone plugs in dry eye syndrome.
Am J Ophthalmol. 2001 Jan;131(1):30-6. doi: 10.1016/s0002-9394(00)00620-6.
8
Punctal Plug Retention Rates for the Treatment of Moderate to Severe Dry Eye: A Randomized, Double-Masked, Controlled Clinical Trial.
Am J Ophthalmol. 2015 Aug;160(2):238-242.e1. doi: 10.1016/j.ajo.2015.05.013. Epub 2015 May 18.
9
Punctal occlusion for dry eye syndrome: summary of a Cochrane systematic review.
Br J Ophthalmol. 2019 Mar;103(3):301-306. doi: 10.1136/bjophthalmol-2018-313267. Epub 2018 Oct 18.
10
[Economic impact of overactive bladder symptoms in Japan].
Nihon Hinyokika Gakkai Zasshi. 2008 Nov;99(7):713-22. doi: 10.5980/jpnjurol1989.99.713.

引用本文的文献

1
Abnormal meibum is associated with mutation and IFAP syndrome 2.
medRxiv. 2025 Jul 27:2025.07.25.25332204. doi: 10.1101/2025.07.25.25332204.
2
Remote Eye Triage: Health Economic Perspectives on Resource Prioritization.
Health Serv Insights. 2025 Jun 26;18:11786329251347684. doi: 10.1177/11786329251347684. eCollection 2025.
3
AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye.
Invest Ophthalmol Vis Sci. 2022 Nov 1;63(12):18. doi: 10.1167/iovs.63.12.18.
4
Estimated Annual Economic Burden of Dry Eye Disease Based on a Multi-Center Analysis in China: A Retrospective Study.
Front Med (Lausanne). 2021 Dec 1;8:771352. doi: 10.3389/fmed.2021.771352. eCollection 2021.
7
Dry eye disease ranking among common reasons for seeking eye care in a large US claims database.
Clin Ophthalmol. 2019 Feb 1;13:225-232. doi: 10.2147/OPTH.S188314. eCollection 2019.
8
Reflections on Dry Eye Syndrome Treatment: Therapeutic Role of Blood Products.
Front Med (Lausanne). 2018 Feb 23;5:33. doi: 10.3389/fmed.2018.00033. eCollection 2018.

本文引用的文献

1
Work productivity loss in patients with dry eye disease: an online survey.
Curr Med Res Opin. 2011 May;27(5):1041-8. doi: 10.1185/03007995.2011.566264. Epub 2011 Mar 21.
2
Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndrome.
Jpn J Ophthalmol. 2010 Jul;54(4):259-65. doi: 10.1007/s10384-010-0812-2. Epub 2010 Aug 11.
3
First-year treatment costs among new initiators of topical prostaglandin analogs.
Clin Ophthalmol. 2009;3:637-44. doi: 10.2147/opth.s7113. Epub 2009 Nov 16.
4
Etiology, prevalence, and treatment of dry eye disease.
Clin Ophthalmol. 2009;3:405-12. doi: 10.2147/opth.s5555. Epub 2009 Jul 14.
6
Prevalence, burden, and pharmacoeconomics of dry eye disease.
Am J Manag Care. 2008 Apr;14(3 Suppl):S102-6.
7
Economic burden of bilateral neovascular age-related macular degeneration: multi-country observational study.
Pharmacoeconomics. 2008;26(1):57-73. doi: 10.2165/00019053-200826010-00006.
8
Impact of dry eye syndrome on vision-related quality of life.
Am J Ophthalmol. 2007 Mar;143(3):409-15. doi: 10.1016/j.ajo.2006.11.060. Epub 2007 Jan 2.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验