Klinger Marco, Caviggioli Fabio, Klinger Francesco, Villani Federico, Arra Erseida, Di Tommaso Luca
Plastic Surgery Unit;
Can J Plast Surg. 2011 Summer;19(2):42-4. doi: 10.1177/229255031101900210.
Tuberous breasts are widely known and described. Several surgical strategies have been proposed; however, few studies explain the origin or structural alterations of this deformity. No histological studies have been performed. The present article describes a morphological and histological study of breast tissue specimens.
Mammary specimens of 22 female and five male patients with tuberous breasts were histologically analyzed and compared with six specimens harvested from normal female breasts and from three cases of true 'normal' gynecomastia.
A high prevalence of one histological subtype was observed, with the presence of collagen fibres among few fibroblasts. Histochemical analysis highlighted alterations of the arrangement and of the quantity of collagen involving breast structures.
Results of the present study suggest that collagen deposition alterations can better explain breast parenchyma modifications. Histological features of male subjects support this theory. Additionally, the observation of two cases in male homozygous twins suggests the role of genetic influences.
管状乳房广为人知且有相关描述。已经提出了几种手术策略；然而，很少有研究解释这种畸形的起源或结构改变。尚未进行组织学研究。本文描述了对乳房组织标本的形态学和组织学研究。
对22名患有管状乳房的女性患者和5名男性患者的乳腺标本进行组织学分析，并与从正常女性乳房以及3例真正“正常”男性乳房肥大病例中获取的6个标本进行比较。
观察到一种组织学亚型的高患病率，在少数成纤维细胞中有胶原纤维存在。组织化学分析突出了涉及乳房结构的胶原排列和数量的改变。
本研究结果表明，胶原沉积改变可以更好地解释乳腺实质的改变。男性受试者的组织学特征支持这一理论。此外，在男性同卵双胞胎中观察到的两例病例表明了遗传影响的作用。
