Grisaru Silviu, Midgley Julian P, Hamiwka Lorraine A, Wade Andrew W, Samuel Susan M
Division of Nephrology, Alberta Children's Hospital, Department of Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta.
Paediatr Child Health. 2011 Jun;16(6):337-40. doi: 10.1093/pch/16.6.337.
Reports of long-term incidence trends of endemic diarrhea-associated hemolytic uremic syndrome (D+HUS) are few and inconclusive.
To define and analyze the incidence and outcomes of D+HUS over a period of approximately 25 years in a highly endemic region of southern Alberta.
Annual incidence rates of confirmed cases of D+HUS were compared between two 12-year periods (1980 to 1992 and 1994 to 2006). Differences in therapies used, and some short- and long-term complications observed were also compared between the two periods.
The absolute yearly number of D+HUS cases was highly variable. The comparison between the 1980 to 1992, and 1994 to 2006 periods demonstrated a modest 8.8% decrease in the total number of cases. The population-based average annual incidence rates were not significantly different between the two time periods (3.33 cases versus 2.58 cases per 100,000 population per year, respectively; P=0.30). Only supportive care measures were used in the latter period. A mortality rate of lower than 1% in the latter period was one of the lowest ever reported for a large cohort of D+HUS patients.
The present long-term retrospective study of D+HUS in a highly endemic area documented a modest decrease in the absolute number of cases but no difference in the average annual incidence over an extended period of time.
关于地方性腹泻相关性溶血尿毒综合征（D+HUS）长期发病率趋势的报道较少且尚无定论。
明确并分析阿尔伯塔省南部一个高度流行地区约25年间D+HUS的发病率及转归情况。
比较两个12年期间（1980年至1992年和1994年至2006年）确诊的D+HUS病例的年发病率。还比较了两个时期所采用治疗方法的差异以及观察到的一些短期和长期并发症。
D+HUS病例的绝对年数变化很大。1980年至1992年与1994年至2006年期间的比较显示病例总数有适度的8.8%下降。两个时间段基于人群的年平均发病率无显著差异（分别为每年每10万人口3.33例和2.58例；P=0.30）。后一时期仅采用了支持性护理措施。后一时期低于1%的死亡率是大量D+HUS患者队列中所报道的最低死亡率之一。
目前在一个高度流行地区对D+HUS进行的长期回顾性研究表明，病例绝对数有适度下降，但在较长时间段内年平均发病率无差异。
