Sanders Brown Center on Aging, University of Kentucky, Lexington KY, USA.
Curr Neuropharmacol. 2011 Dec;9(4):651-61. doi: 10.2174/157015911798376217.
Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimer's Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregation and increased clearance of Aβ. The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting Aβ.
老年犬和人类在衰老方面具有复杂的认知和病理反应。具体来说，狗会出现类似于阿尔茨海默病（AD）的β-淀粉样蛋白（Aβ），这与认知缺陷有关。目前，预防 AD 的治疗方法主要针对减少 Aβ的产生、聚集和增加其清除。本文综述了衰老犬模型的认知和神经病理学，以及它在进一步理解针对 Aβ的潜在 AD 预防治疗的安全性和疗效方面的作用和持续作用。
