Romanucci Mariarita, Della Salda Leonardo
Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.
Oxid Med Cell Longev. 2015;2015:940131. doi: 10.1155/2015/940131. Epub 2015 May 11.
Aged dogs are considered the most suitable spontaneous animal model for studying normal aging and neurodegenerative diseases. Elderly canines naturally develop cognitive dysfunction and neuropathological hallmarks similar to those seen in humans, especially Alzheimer's disease-like pathology. Pet dogs also share similar living conditions and diets to humans. Oxidative damage accumulates in the canine brain during aging, making dogs a valid model for translational antioxidant treatment/prevention studies. Evidence suggests the presence of detective protein quality control systems, involving ubiquitin-proteasome system (UPS) and Heat Shock Proteins (HSPs), in the aged canine brain. Further studies on the canine model are needed to clarify the role of age-related changes in UPS activity and HSP expression in neurodegeneration in order to design novel treatment strategies, such as HSP-based therapies, aimed at improving chaperone defences against proteotoxic stress affecting brain during aging.
老年犬被认为是研究正常衰老和神经退行性疾病最合适的自发动物模型。老年犬自然会出现认知功能障碍和神经病理学特征,类似于人类所见,尤其是阿尔茨海默病样病理特征。宠物犬的生活条件和饮食也与人类相似。衰老过程中犬脑会积累氧化损伤,这使得犬成为转化抗氧化治疗/预防研究的有效模型。有证据表明,老年犬脑中存在有缺陷的蛋白质质量控制系统,涉及泛素-蛋白酶体系统(UPS)和热休克蛋白(HSPs)。需要对犬模型进行进一步研究,以阐明UPS活性和HSP表达的年龄相关变化在神经退行性变中的作用,从而设计新的治疗策略,如基于HSP的疗法,旨在增强伴侣蛋白防御机制,抵御衰老过程中影响大脑的蛋白毒性应激。