Division of Anatomic Pathology and Histology, "Agostino Gemelli" School of Medicine and Hospital, Università Cattolica del Sacro Cuore Rome, Italy.
Front Endocrinol (Lausanne). 2012 May 16;3:57. doi: 10.3389/fendo.2012.00057. eCollection 2012.
Fine-needle aspiration biopsy is regarded as an important tool for diagnosing thyroid lesions because of its simplicity, safety, and cost-effectiveness. Its role in correctly characterizing the group of indeterminate lesions or follicular-patterned neoplasms (FN) might be more decisive. Liquid-based cytology (LBC) is a technique based on the use of a semi-automated device that has gained popularity as a method of collecting and processing both gynecologic and non-gynecologic cytologic specimens. It achieves a diagnostic sensitivity as accurate as conventional preparations especially for its excellent cell preservation and for the lack of background which decrease the amount of inadequate diagnoses. Moreover, the cellular material which has been stored in the preservative solution could be effectively used for the application of immunocytochemical and molecular techniques especially for the Follicular proliferations. In many cases the cytologic features are similar in both methods but the colloid film and the lymphocytic component are more easily evaluated on direct smears whereas nuclear details and colloid globules are better evaluated in LBC slides. The LBC-processed biopsies represent a valid alternative to conventional cytology. The possibility of applying special techniques enhance the efficacy of the cytological diagnosis of thyroid lesions.
细针抽吸活检被认为是诊断甲状腺病变的重要工具，因为它简单、安全且具有成本效益。它在正确描述不确定病变或滤泡性肿瘤（FN）组中的作用可能更为决定性。液基细胞学（LBC）是一种基于使用半自动设备的技术，已作为收集和处理妇科和非妇科细胞学标本的方法而广受欢迎。它实现了与传统制剂一样准确的诊断敏感性，特别是因为其出色的细胞保存和缺乏背景，可以减少不充分诊断的数量。此外，储存在防腐剂溶液中的细胞材料可以有效地用于免疫细胞化学和分子技术的应用，特别是对于滤泡增生。在许多情况下，两种方法的细胞学特征相似，但直接涂片更容易评估胶体膜和淋巴细胞成分，而 LBC 载玻片上可以更好地评估核细节和胶体小球。LBC 处理的活检是常规细胞学的有效替代方法。应用特殊技术的可能性提高了甲状腺病变的细胞学诊断效果。
